3308-98-3Relevant articles and documents
Oxacycle synthesis via intramolecular reaction of carbanions and peroxides
Willand-Charnley, Rachel,Puffer, Benjamin W.,Dussault, Patrick H.
supporting information, p. 5821 - 5823 (2014/05/20)
The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.
6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists
-
Page/Page column 22-23, (2008/12/08)
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: Formula (I) where: R6 is selected from the group consisting of (a, b, c, d, e) and other substituents are as defined in the specification.
Synthesis of 1-aryl-4-azolylbutanones
Karachev,Popkov
, p. 987 - 993 (2007/10/03)
A convenient method was developed for the synthesis of substituted 4-azolyl-1-arylbutanones from the available γ-chlorobutyrophenones by successive stages of transformation into ketals, alkylation of sodium imidazolate or 1,2,4-triazolate by the ketals in