330814-51-2

Upstream product

• 98541-64-1 (S)-3-(tert-butoxycarbonylamino)-oxetan-2-one 
• 330814-50-1 (5-bromo-1-ethyl-pentyloxy)-tert-butyl-diphenyl-silane 
• 111-29-5 1 ,5-pentanediol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 83067-20-3 5-(tert-butyldimethyl-silyloxy)pentan-1-ol 
• 87184-80-3 5-tert-butyldimethylsilyloxypentanal 

Downstream Products

• 330814-54-5 1-{2-[2-[2-tert-butoxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-decanoylamino]-3-(1-methoxy-1H-indol-3-yl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carboxylic acid methyl ester 
• 330814-52-3 2-[2-tert-butoxycarbonylamino-8-(tert-butyl-diphenyl-silanyloxy)-decanoylamino]-3-(1-methoxy-1H-indol-3-yl)-propionic acid 
• 183506-66-3 apicidin 

Relevant academic research and scientific papers

Synthesis of apicidin

Tetrapeptide containing L-2-amino-8-protected hydroxydecanoic acid, L-N-O-methyltryptophan, L-isoleucine and D-pipecolinic acid was cyclized with pentafluorophenyl diphenylphosphinate. The cyclic tetrapeptide was deprotected and oxidized to apicidin [cyclo-(N-O-methyl-L-Trp-L-Ile-D-Pip-L-2-amino-8-oxo-decanoyl)].