330821-83-5

Basic information

• Product Name: C₂₀H₁₅ClN₂O₂
• Synonyms: C₂₀H₁₅ClN₂O₂
• CAS NO: 330821-83-5
• Molecular Weight: 350.804
• Mol File: 330821-83-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₅ClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₅ClN₂O₂(330821-83-5)
• EPA Substance Registry System: C₂₀H₁₅ClN₂O₂(330821-83-5)

Safety Data

• Hazardous Substances Data: 330821-83-5(Hazardous Substances Data)

Upstream product

• 6282-15-1 4-chloro-benzoic acid-(3-nitro-anilide) 
• 122-01-0 4-chloro-benzoyl chloride 
• 99-09-2 3-nitro-aniline 
• 98-88-4 benzoyl chloride 
• 905811-04-3 N-(3-amino-phenyl)-4-chloro-benzamide 

Relevant articles and documents

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.