33097-38-0

Usage

Uses

Used in Pharmaceutical Manufacturing:
3-chloro-6-fluoropyridazine is used as a key intermediate in the synthesis of pharmaceuticals. Its unique structure, which includes chlorine and fluorine atoms, allows for the creation of a wide range of complex molecules that can be utilized in the development of new drugs.
Used in Organic Synthesis:
3-chloro-6-fluoropyridazine is employed as a building block in the synthesis of other organic compounds. Its presence in the molecular structure can facilitate the formation of various derivatives, making it a valuable component in the production of specialty chemicals and materials.
Safety Precautions:
While specific safety information for 3-chloro-6-fluoropyridazine may not be readily available, it is recommended to handle this chemical with the same precautions as other chemicals. This includes avoiding direct contact or inhalation and ensuring that it is used in well-ventilated areas to minimize potential health risks.

Upstream product

• 141-30-0 3,6-dichlorpyridazine 
• 5469-69-2 6-chloro-pyridazin-3-ylamine 

Relevant academic research and scientific papers

Deaminative chlorination of aminoheterocycles

Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function

The discovery of reldesemtiv, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit 1 led to compounds with improved free exposure and in vivo muscle activation potency compared to the first-generation FSTA, tirasemtiv. Reldesemtiv demonstrated increased muscle force generation in a phase 1 clinical trial and is currently being evaluated in clinical trials for the treatment of amyotrophic lateral sclerosis.

Selective fluorination by halogen exchange of chlorodiazines and chloropyridines promoted by the 'proton sponge' - Triethylamine tris(hydrogen fluoride) system

The 'proton sponge' - triethylamine tris(hydrogen fluoride) mixtures provide a mild and efficient fluorinating reagent to introduce selectively fluorine atoms by halogen exchange into chlorodiazines and chloronitropyridine series.

The proton sponge-triethylamine tris(hydrogen fluoride) system as a selective nucleophilic fluorinating reagent for chlorodiazines

The proton sponge-triethylamine tris(hydrogen fluoride) mixture provides a mild and efficient fluorinating - reagent for the selective introduction of a fluorine atom, by halogen exchange, into dichlorodiazines. (C) 2000 Elsevier Science Ltd.

Halogen-Exchange Fluorination of Aromatic Halides with HF or HF-Base

Heteroatomic halides such as 2-chloropyrimidines and 2-chloropyridines, and 2,4-dinitrochlorobenzene underwent halogen-exchange fluorination with the treatment of HF or HF-base solutions to afford the corresponding fluorides in good yields.