33104-36-8

Upstream product

• 64-18-6 formic acid 
• 95-95-4 2,4,5-trichlorophenol 
• 1988-17-6 m-nitrophenyl formate 
• 45773-92-0 2,4,5-trichlorophenoxide ion 
• 1865-01-6 (4-nitrophenyl) formate 

Downstream Products

• 33104-17-5 Dichlormethyl-2,4,5-trichlorphenylaether 
• 70637-32-0 formyl-Met-Leu-Phe-OCH₂C₆H₅ 
• 84765-38-8 formyl-Met-Lys(Z)-Pro-Arg(NO₂)-OCH₂C₆H₅ 
• 98229-02-8 For-L-Met-L-Leu-L-Phe-CAM 
• 119706-26-2 For-Met-Leu-Phe-OBg 
• 121888-46-8 Boc-Asp(OBzl)-gPhe-For 

Relevant academic research and scientific papers

Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials

Mutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical prop

Structure-reactivity correlations for reactions of substituted phenolate anions with acetate and formate esters

The reactions of substituted phenolate anions with m-nitrophenyl, p-nitrophenyl, and 3,4-dinitrophenyl formates follow nonlinear Br?nsted-type correlations that might be taken as evidence for a change in the rate-limiting step of a reaction that proceeds through a tetrahedral addition intermediate. However, the correlation actually represents two different Br?nsted lines that are defined by meta- and para-substituted phenolate anions and by meta- and para-substituted o-chlorophenolate anions. A concerted mechanism for both acetyl- and formyl-transfer reactions is supported by the absence of a detectable change in the Br?nsted slope at ΔpK = 0 for the attacking and leaving phenolate anions within each class of Br?nsted correlations. Regular increases in the dependence of log k on the pKa of the nucleophile with increasing pKa of the leaving group correspond to a positive interaction coefficient pxy = ?β1g/?(pKnuc) = ?βnuc/?(pK1g). The observation of two different Br?nsted lines for the reactions of substituted phenolate anions with phenyl acetates is attributed to a steric effect that decreases the rate of reaction of substituted o-chlorophenolate anions by 25-50%. The reactions of meta- and para-substituted phenolate and o-chlorophenolate anions with substituted phenyl acetate esters follow values of βnuc = 0.53-0.66 and -β1g = 0.50-0.63. The reactions of meta- and para-substituted phenolate anions with formate esters are ～ 103 times faster and follow smaller values of βnuc = 0.43-0.64 and -β1g = 0.31-0.48. However, the reactions of meta- and para-substituted o-chlorophenolate anions with the same formate esters follow larger values of βnuc = 0.63-0.90 and -β1g = 0.46-0.90. The large values of βnuc and -β1g for the reactions of substituted o-chlorophenolate anions with formate esters may arise from destabilization by the o-chloro group of a stacking interaction that is present in the transition state for reactions of formate esters, but not acetate esters.