33119-82-3

Usage

Uses

Used in Medicinal Chemistry:
2-[(2E)-2-(4-chlorobenzylidene)hydrazinyl]-1,3-benzothiazole is used as a potential therapeutic agent for various applications due to its benzothiazole core and hydrazine group, which are known to contribute to biological activities such as anticancer, antimicrobial, and antiviral properties.
Used in Organic Synthesis:
In the field of organic synthesis, 2-[(2E)-2-(4-chlorobenzylidene)hydrazinyl]-1,3-benzothiazole is used as a precursor to other biologically active compounds, leveraging its unique structural features to create novel molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, 2-[(2E)-2-(4-chlorobenzylidene)hydrazinyl]-1,3-benzothiazole is utilized as a key intermediate in the development of new drugs, taking advantage of its chemical properties to enhance the therapeutic effects and selectivity of medicinal agents.

Upstream product

• 149-30-4 2-Mercaptobenzothiazole 
• 104-88-1 4-chlorobenzaldehyde 
• 615-21-4 1,3-benzothiazol-2-ylhydrazine 

Downstream Products

• 37120-62-0 N'-benzothiazol-2-yl-4-chloro-benzohydrazonoyl bromide 
• 33119-91-4 3-(4-chlorophenyl)benzo[4,5]thiazolo[2,3-c][1,2,4]triazole 
• 33119-86-7 N-acetyl-N-benzothiazol-2-yl-N'-(4-chloro-benzoyl)-hydrazine 

Relevant academic research and scientific papers

Arylhydrazones Derivatives Containing a Benzothiazole Moiety, Efficient Ligands in the Palladium-Catalyzed Mizoroki–Heck and Suzuki–Miyaura Cross-coupling Reactions under IR Irradiation

A simple arylhydrazone containing the benzothiazole moiety which may be used as an efficient ligand in the palladium-catalyzed Mizoroki–Heck and Suzuki–Miyaura cross-coupling reactions, under infrared irradiation as an alternative source of energy, is presented. The reactions proceeded with extremely high efficiency under mild conditions and produced very good yields.

Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones

Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines

Synthesis of new triazolo and pyrazolo benzothiazoles

Benzothiazole-2-thiol 1 on heating with excess of hydrazine hydrate yields 2-hydrazino-1,3-benzothiazole (2). Compound 2 on reaction with carbon disulfide in alkaline medium affords [1,2,4] triazolo [3,4-b] [1,3] benzothiazole-3-thiol (3). Condensation of 2 with various substituted aryl aldehydes yields corresponding hydrazine derivatives (4), which on cyclisation with acetic anhydride gave corresponding [1,2,4] triazolo [3,4-6] [1,3] benzothiazoles (5). Some other triazolo derivatives (6,7,8) of benzothiazole were obtained by the cyclization of 2 with benzoyl chloride, acetyl chloride and formic acid respectively. Again compound 2 on condensation with acetyl acetone and ethylacetoacetate gives pyrazolo derivatives (9,10) respectively. The synthesized compounds were characterized by elemental and spectral analysis.

Synthesis and antitumor evaluation of (E)-2-benzothiazole hydrazones

A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cy

Preparation and Spectroscopic Properties of 2-Benzothiazolyl Araldehyde Hydrazones

Notwithstanding its tendency toward air oxidation in solution, 2-hydrazinobenzothiazole I reacted with aromatic aldehydes in ethanol to give the corresponding hydrazones III-XV in high yields and analytical purity.In related examples, acylation took place

Synthesis and Reactions of 2-Mercaptobenzothiazole Derivatives of Expected Biological Activity. 2

The amides and anilides of benzothiazol-2-ylthioacetic acid and 3-(benzothiazol-2-ylthio)propanoic acid were prepared by the reaction of the corresponding acid chlorides with amines and anilines.Also the arylhydrazones, the cycloalkanone hydrazones, and pyrazoline derivatives were prepared.