33140-27-1

Upstream product

• 5006-20-2 5-ethoxy-4-methyl-oxazole 
• 5417-35-6 2-isopropyl-4,7-dihydro-[1,3]dioxepine 
• 17344-99-9 AlaOEt 
• 4289-99-0 ethyl N-formyl-2-aminopropanoate 

Downstream Products

• 38062-14-5 4-Cyano-2-methyl-2-methyleneamino-3-phenyl-butyric acid ethyl ester 
• 32755-49-0 2-Isocyan-2-methyl-3-(phenylthio)propionsaeureethylester 
• 32755-48-9 (+/-)-2-(2-Carboethoxy-1-phenyl)propylisocyanid 
• 27772-67-4 4-methyl-5-phenyl-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester 
• 40107-74-2 5-(3,4-dimethoxy-phenyl)-4-methyl-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester 
• 40107-74-2 5c-(3,4-dimethoxy-phenyl)-4-methyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester 
• 114968-86-4 2-Cyclohex-2-enyl-2-isocyano-propionic acid ethyl ester 
• 63348-62-9 N-Benzyl-2-isocyanpropionsaeureamid 
• 86769-69-9 2-Cyclohex-2-enyl-propionic acid ethyl ester 
• 71920-97-3 D,L-3-(1-benzoyl-2,3-dihydro-1H-indole-5-yl)-2-isocyano-2-methylpropionic acid ethyl ester 
• 1098215-31-6 ethyl N-benzyl-3,3,3-trifluoro-N-(trifluoroacetyl)alanylalaninate 
• 1098215-41-8 ethyl 2-({2-[benzy(trifluoroacetyl)amino]-3,3,3-trifluoro-2-methylpropanoyl}amino)propanoate 
• 1187066-86-9 C₂₁H₂₇F₃N₂O₇ 
• 1613081-86-9 C₂₀H₂₃N₃O₃ 

Relevant academic research and scientific papers

Enantioselective synthesis of 1,2,4-triazolines by chiral iron(ii)-complex catalyzed cyclization of α-isocyano esters and azodicarboxylates

Enantioselective cyclization of α-isocyano esters with azodicarboxylates catalyzed by FeII-N,N′-dioxide complexes has been developed. Under mild conditions, a variety of 1,2,4-triazoline derivatives was obtained in high yields and enantioselectivities.

MANUFACTURE OF VITAMIN B6

A process for manufacturing a 3-unsubstituted, 3-monosubstituted or 3,3-disubstituted 9-acyloxy-1,5-dihydro-8--methylpyrido[3,4-e] [1,3]dioxepin (I) and optionally for manufacturing pyridoxine involves performing an addition reaction between a 4-methyl-5-alkoxy-oxazole (II) and a 2-unsubstituted, 2-monosubstituted or 2,2-disubstituted 4,7-dihydro-(1,3)-dioxepin (III) in the substantial absence of a solvent and a catalyst to give a product mixture consisting essentially of the appropriate Diels-Alder adduct (IV) in a major proportion and the appropriate 3--unsubstituted, 3-monosubstituted or 3,3-disubstituted 1,5-dihydro-8-methylpyrido[3,4-e] [1,3]dioxepin 9-ol (V) in a minor proportion, removal of a substantial proportion of the unreacted oxazole and dioxapin starting materials from the product mixture by distillation under reduced pressure, addition of a substantially anhydrous organic acid to said product mixture and rearrangement of the Diels-Alder adduct IV to further V in the presence of said substantially anhydrous organic acid with removal of the generated alkanol by distillation under reduced pressure, and acylation of the resultingly enriched quantity of V with an added carboxylic acid anhydride to produce the desired I, and optionally converting this so-manufactured acylation product I to pyridoxine by acid hydrolysis for achieving deprotection and deacylatiom. Pyridoxine is a well known form of vitamin B6 with well established utility.