331416-68-3Relevant academic research and scientific papers
Discovery of 6-aryl-azabenzimidaoles that inhibit the TBK1/IKK-ε kinases
Johannes, Jeffrey W.,Chuaqui, Claudio,Cowen, Scott,Devereaux, Erik,Gingipalli, Lakshmaiah,Molina, Audrey,Wang, Tao,Whitston, David,Wu, Xiaoyun,Zhang, Hai-Jun,Zinda, Michael
, p. 1138 - 1143 (2014/03/21)
The discovery and optimization of a series of 6-aryl-azabenzimidazole inhibitors of TBK1 and IKK-ε is described. Various internal azabenzimidazole leads and reported TBK1/IKK-ε inhibitors were docked into a TBK1 homology model. The resulting overlays insp
Synthesis of fused imidazoles and benzothiazoles from (hetero)aromatic ortho-diamines or ortho-aminothiophenol and aldehydes promoted by chlorotrimethylsilane
Ryabukhin, Sergey V.,Plaskon, Andrey S.,Volochnyuk, Dmitriy M.,Tolmachev, Andrey A.
, p. 3715 - 3726 (2008/03/14)
New convenient conditions for benzimidazole and benzothiazole syntheses are described. A set of benzimidazoles, 3H-imidazo[4,5-b]pyridines, purines, xanthines and benzothiazoles was readily prepared from (hetero)aromatic ortho-diamines or ortho-aminothiop
Studies on aroylation of 2,3-pyridinediamines
Dubey,Vinod Kumar
, p. 746 - 751 (2007/10/03)
The reaction of 2,3-pyridinediamine 1a and its 5-bromo analogue 1b, independently, with acid chloride or anhydride does not yield the diaroyl derivative and instead yields the cyclised product 3 or the monoaroyl derivative 4 depending upon the conditions.
