33158-52-0

Basic information

• Product Name: 1-benzyl-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
• Synonyms: 1-benzyl-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
• CAS NO: 33158-52-0
• Molecular Weight: 238.289
• Mol File: 33158-52-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one(33158-52-0)
• EPA Substance Registry System: 1-benzyl-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one(33158-52-0)

Safety Data

• Hazardous Substances Data: 33158-52-0(Hazardous Substances Data)

Upstream product

• 1632-83-3 1-Methylbenzimidazole 
• 46818-46-6 1-methyl-1H-benzo[d]imidazol-2-yl phenyl sulfide 
• 4981-92-4 1-benzylbenzimidazole 
• 56463-13-9 1-benzyl-3-methyl-1H-benzimidazol-3-ium iodide 
• 74-88-4 methyl iodide 
• 620-05-3 iodomethylbenzene 
• 108-88-3 toluene 

Downstream Products

• 1849-01-0 1-methyl-2-benzimidazolone 

Relevant articles and documents

TEMPO-Mediated Synthesis of N-(Fluoroalkyl)imidazolones via Reaction of Imidazoles with Iodofluoroacetate

We report a TEMPO-mediated oxidative copper-catalyzed synthesis of N-(fluoroalkyl)imidazolones via the radical addition of imidazoles with iodofluoroacetate. A possible key intermediate involving TEMPO was observed by ESI-MS. We also found that aerobic ox

Metal-free C(sp2)-H functionalization of azoles: K2CO3/I2-mediated oxidation, imination, and amination

The direct C2-H oxidation and imination of a wide variety of azoles was achieved by using a commercially available simple K2CO3/I2 reagent combination. The iodinated azole adduct, produced via the in situ generation of N-heterocyclic carbene, is the key intermediate for C2-H oxidation, imination, and amination of azoles. Significantly, these reactions proceed under mild conditions with high to excellent yields, are scalable to large quantity and exhibit a broad substrate scope. Interestingly, this direct C2-H imination method allowed us to access various pharmacologically active N6-alkyl or N6-aryl substituted benzimidazoquinazolinone scaffolds through intramolecular C-H imination in a sequential one-pot reaction.

Synthesis of 2-imidazolones and 2-iminoimidazoles

Convenient methods for the direct conversion of imidazolium salts to the corresponding 2-imidazolone or 2-imino imidazole derivatives have been developed. Treatment of the salt with commercial bleach leads to effective oxidation at C2 and the formation of the corresponding imidazolone. Alternatively, treatment of the salt with an N-chloro amide affords the corresponding protected 2-amino derivative in good yield.