Journal of labelled compounds and radiopharmaceuticals p. 21 - 30 (2001)
Update date:2022-08-05
Topics:
Hasegawa, Hiroshi
Shinohara, Yoshihiko
Tagoku, Kazunori
Hashimoto, Takao
Optically pure L-[3,3,4,4,S-methyl-2H7]methionine (L-[2H7]methionine) for use as a substrate for the methionine loading test has been prepared. The racemic [2H7]methionine was prepared from DL-[3,3,4,4-2H4]methionine (DL-[2H4]methionine) by conversion of the S-CH3 group to a C2H3 group. The racemate was resolved by stereospecific hydrolysis of the N-acetylated derivative with acylase. After an intravenous administration of L-[2H7]methionine in a rat, the concentration of L-[2H7]methionine and the metabolites in plasma were determined by GC-MS-SIM. L-[2H4]Homocysteine and L-[2H4]methionine were detected in plasma at 30 min after dosing. These results show that L-[2H7]methionine was converted by de-methylation and subsequent remethylation to form L-[2H4] methionine.
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