33173-34-1

Basic information

• Product Name: (S)-2-hydroxy-3-(4-methoxyphenyl)propanoic acid
• Synonyms: (S)-2-hydroxy-3-(4-methoxyphenyl)propanoic acid
• CAS NO: 33173-34-1
• Molecular Weight: 196.203
• Mol File: 33173-34-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-2-hydroxy-3-(4-methoxyphenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-hydroxy-3-(4-methoxyphenyl)propanoic acid(33173-34-1)
• EPA Substance Registry System: (S)-2-hydroxy-3-(4-methoxyphenyl)propanoic acid(33173-34-1)

Safety Data

• Hazardous Substances Data: 33173-34-1(Hazardous Substances Data)

Upstream product

• 1214260-73-7 (Z)-2-ethoxy-3-(4-methoxyphenyl)propenoic acid 
• 343880-41-1 (S)-2-ethoxy-3-(4-methoxyphenyl)propanoic acid 
• 108-05-4 vinyl acetate 
• 38618-53-0 ethyl 2-hydroxy-3-(4-methoxyphenyl)propanoate 
• 6230-11-1 O-Methyltyrosine 
• 17131-20-3 3-(4′-methoxyphenyl)-prop-1,2-diol 
• 30193-56-7 (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4''-methoxyphenyl)-propionic acid methyl ester 
• 42245-42-1 methyl 3-(4-methoxyphenyl)glycidate 
• 105955-68-8 p-methoxybenzyltartronic acid monoamide 
• 55301-58-1 2-hydroxy-3-(4-methoxyphenyl)propionic acid methyl ester 
• 133373-30-5 4-(p-methoxyphenyl)-2,3-diketobutyramide hydrate 

Downstream Products

• 1206734-19-1 ethyl (S)-2-hydroxy-3-(4-methoxyphenyl)propanoate 

Relevant articles and documents

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer

The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.

Claisen condensation as a facile route to an α-alkoxy-cinnamate: Synthesis of ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

The title compound was prepared from p-anisaldehyde and ethyl ethoxyacetate via a racemic synthetic route. The synthesis involves a Claisen-type condensation in which the elimination was unexpectedly promoted by an excess of the ester. The process has been successfully performed on a 2000-L scale with a total yield over seven steps of 19%.

Unstable 1,1,2-Enetriols as (Probable) Intermediates in the Decarboxylation of α,β-Diketo Acids

During the acid hydrolysis of (hydrated) 4-aryl-2,3-diketobutyramide 2 (aryl = phenyl, o-chlorophenyl, p-methoxyphenyl), 3-aryllactic acid (5) is formed by rapid decarboxylation of the intermediate diketo acid (3).In the decarboxylation step, a further unstable intermediate is formed.The latter manifests itself by reducing 1 mol of added iodine during the hydrolysis-decarboxylation reaction, thereby forming 3-arylpyruvic acid (6), isolated instead of 5.Thus, the oxidation of the unstable intermediate by iodine is more rapid than its ketonization.It is formulated as an 1,1,2-enetriol (4), more probably than an α-hydroxyketone.