33173-35-2Relevant academic research and scientific papers
An efficient enzymatic aminolysis for kinetic resolution of aromatic α-hydroxyl acid in non-aqueous media
Chen, Shan,Liu, Fuyan,Zhang, Kuan,Huang, Hansheng,Wang, Huani,Zhou, Jiaying,Zhang, Jing,Gong, Yiwei,Zhang, Dela,Chen, Yiping,Lin, Chang,Wang, Bo
supporting information, p. 5312 - 5314 (2016/11/16)
A new and highly efficient enzymatic aminolysis approach for kinetic resolution of aromatic α-hydroxy acid in non-aqueous media has been developed. The corresponding α-hydroxyl acid ester was employed as the substrate, and commercially available Candida antarctica lipase B is used as the biocatalyst, anhydrous ammonia is the resolving agent. Reactions can be proceeded smoothly in organic solvent at ambient temperatures. High concentration of substrate is allowed due to the application of organic media and the products are obtained in yields of up to 49% with ee values of up to 99%, and with E value of >300, representing an appealing and promising protocol for large-scale preparations.
THIENOPYRIDINE-PHENYLACET AMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS
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Page/Page column 88, (2010/02/11)
The invention relates to compounds represented by Formula (I):, and to prodrugs thereof, pharmaceutically salts or solvates of said compounds or said prodrugs, wherein each of X1-X5 and R1-R5 are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
Electron-transfer Processes: Oxidation of Arylacetic Acids by Peroxydisulphate in Acetic Acid
Giordano, Claudio,Beili, Aldo,Citterio, Attilio,Minisci, Francesco
, p. 1574 - 1576 (2007/10/02)
The oxidation of arylacetic acids by peroxydisulphate in acetic acid media in the presence of potassium and copper(II) acetates leads to the corresponding benzylacetates.The mechanism of the reaction is rationalized by the occurrence of two pathways: the intermediate formation of aromatic radical cations or the direct decarboxylation of the arylacetate ion.The importance of acetic acid as reaction medium is stressed.
