331755-36-3

Upstream product

• 76-83-5 trityl chloride 
• 79356-74-4 ethyl tetrahydro-4(S)-hydroxy-5(R)-<((triphenylmethyl)oxy)methyl>-2(R)-furanacetate 
• 124290-99-9 (4S,5R)-5-((trityloxy)methyl)tetrahydrofuran-2,4-diol 
• 452-51-7 D-2-deoxyribose 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 331755-37-4 9-[4-((2S,4S,5R)-4-Methoxymethoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-butyl]-6-vinyl-9H-purin-2-ylamine 

Relevant academic research and scientific papers

Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation

A new nucleoside derivative (2) with a butyl spacer between the sugar part and the 2-amino-6-vinylpurine motif has been synthesized. The triplex-forming oligodeoxynucleotide incorporating 2 has achieved strand- and cytidine-selective cross-linking reaction to the G-C target site mediated by triple helix formation. It has been suggested that 2 reacts with a flipping cytidine at the target site.