331811-71-3

Upstream product

• 5455-59-4 2-Nitrobenzenesulfonamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 1024128-43-5 C₁₇H₂₁N₂O₇PS 
• 1161989-06-5 (-)-(3S,4R)-3-ethyl-4-(2-nitrophenylsulfonamido)-2-oxo-N,4-diphenylbutanamide 
• 1161989-04-3 (-)-(3S,4R)-3-methyl-4-(2-nitrophenylsulfonamido)-2-oxo-N,4-diphenylbutanamide 
• 645-49-8 cis-stilben 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 1258869-49-6 C₂₀H₁₆N₂O₄S 
• 1258869-48-5 C₂₀H₁₆N₂O₄S 
• 1073451-21-4 C₂₁H₂₄N₂O₇S 
• 5422-81-1 (E)-3-phenyl-1-(piperidin-1-yl)-prop-2-en-1-one 
• 24840-05-9 (Z)-cinnamonitrile 
• 4610-69-9 (Z)-ethyl cinnamate 
• 4192-77-2 ethyl cinnamate 
• 1294493-77-8 2-methylene-4-nitro-3-phenylbutanenitrile 
• 1294493-94-9 C₂₈H₂₃N₂O₂P 

Relevant academic research and scientific papers

Catalytic asymmetric synthesis of dihydroquinazolinones from imines and 2-aminobenzamides

An unprecedented catalytic asymmetric synthesis of aminal-containing heterocyclic compounds has been developed from imines and tethered nitrogen/nitrogen nucleophiles. In the presence of 10mol% of a commercially available chiral phosphoric acid, a range of aromatic, α,β- unsaturated, and aliphatic imines react with 2-aminobenzamides to give dihydroquinazolinones in good to excellent yields and ee. The enantioselectivity is significantly affected by the imine N-substituent through non-bonding interactions with the chiral phosphoric acid and the 2-aminobenzamide. Copyright

A highly tunable stereoselective olefination of semistabilized triphenylphosphonium ylides with N -Sulfonyl imines

The Wittig reaction involving direct olefination of triphenylphosphonium ylides (Ph3PCHR) with aldehydes is arguably the most often used method for alkene synthesis, but in general it yields mixtures of Z- and E-alkenes for semistabilized triphenylphosphonium ylides (R = aryl or vinyl). We have developed a simple and efficient protocol to improve the stereoselectivity significantly by replacing the aldehydes used in the Wittig reaction with N-sulfonyl imines, which possess distinct electronic and steric properties relative to aldehydes. A broad range of aromatic, α,β-unsaturated, and aliphatic imines bearing appropriate N-sulfonyl groups smoothly undergo olefination reaction with various benzylidenetriphenylphosphoranes or allylidenetriphenylphosphoranes under mild reaction conditions to afford an array of both Z- and E-isomers of conjugated alkenes in good to excellent yields and with greater than 99:1 stereoselectivity. Moreover, this tunable protocol has been successfully applied to the highly stereoselective synthesis of two anticancer agents, DMU-212 and its Z-isomer.