340774-75-6

Upstream product

• 137898-16-9 2-allyl-3-methoxynitrobenzene 
• 621-42-1 meta-hydroxyacetanilide 
• 37439-78-4 N-(3-(allyloxy)phenyl)acetamide 
• 37439-79-5 2-allyl-3-acetamidophenol 
• 340774-74-5 acetic acid-(2-allyl-3-methoxy-anilide) 

Downstream Products

• 331819-84-2 (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester 
• 340774-81-4 (S)-3-[2-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-2-((R)-2-hydroxy-1-phenyl-ethylamino)-propionic acid methyl ester 
• 331819-86-4 (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid 
• 340774-79-0 (S)-3-[2-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-2-((R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile 
• 340774-84-7 {2-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid tert-butyl ester 
• 340774-82-5 2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester 
• 331819-82-0 [2-(2-amino-6-methoxy-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester 
• 340774-77-8 3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propane-1,2-diol 
• 340774-78-9 [2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-acetaldehyde 

Relevant academic research and scientific papers

Highly stereoselective 7-endo-trig /ring contraction cascade to construct pyrrolo[1,2- a ]quinoline derivatives

With the cooperation of Cram's phenonium ion, a novel cascade reaction was illustrated to construct pyrrolo[1,2-a]quinolines as a sole diastereoisomer in good to excellent yields. Preliminary mechanistic studies revealed that the γ-lactam ring and electron-rich arene are important driving forces for ring contraction.

Synthesis of 7-methoxybenzolactam-V8 using a diastereoselective Strecker synthesis

7-Methoxybenzolactam-V8 (4) was synthesized using a diastereoselective Strecker reaction as the key step employing an ortho-substituted phenylacetaldehyde and (R)-phenylglycinol as the chiral auxiliary.