33184-48-4

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-2-IODOTOLUENE is used as a synthetic intermediate for the production of various pharmaceuticals. Its unique halogenated structure allows for the creation of complex organic molecules that can be utilized in the development of new drugs and medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-2-IODOTOLUENE serves as a key intermediate in the synthesis of agrochemicals, including pesticides and herbicides. Its chemical properties enable the development of effective and targeted agricultural products.
Used in Dye and Pigment Production:
4-CHLORO-2-IODOTOLUENE is also utilized as an intermediate in the manufacturing process of dyes and pigments. Its halogenated nature contributes to the color intensity and stability of these products, making it a valuable component in this industry.
Safety Considerations:
Given its potential harmful effects if swallowed, inhaled, or in contact with skin, 4-CHLORO-2-IODOTOLUENE requires careful handling and adherence to proper safety protocols during its use in various applications.

InChI:InChI=1/C7H6ClI/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3

Upstream product

• 95-79-4 5-chloro-2-methyl-benzenamine 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 13421-13-1 4-chloro-2-iodobenzoic acid 
• 86456-23-7 2-(5-chloro-2-methylphenoxy)-5-methoxybenzoic acid 
• 19482-17-8 5-chloro-2-methyl-1,1'-biphenyl 
• 343929-11-3 1-(bromomethyl)-4-chloro-2-iodobenzene 
• 86455-96-1 1-<<2-(dimethylamino)ethyl>amino>-7-hydroxy-4-methyl-9H-xanthen-9-one hydroiodide 
• 86455-94-9 1-<<2-(diethylamino)ethyl>amino>-7-hydroxy-4-methyl-9H-xanthen-9-one hydroiodide 
• 148839-33-2 (5-chloro-2-methylphenyl)boronic acid 
• 1076191-94-0 tert-butyl (5-chloro-2-methylphenyl)acetate 
• 1188412-51-2 (2R)-1-(5-chloro-2-methylphenyl)propan-2-ol 
• 1378976-03-4 4-(5-chloro-2-methylphenyl)-1H-1,2,3-triazole 
• 74331-72-9 1-(5-Chloro-2-methylphenyl)acetylene 
• 1378976-83-0 C₁₂H₁₅ClSi 
• 58966-34-0 5-chloro-2-methylbenzaldehyde 
• 1188411-18-8 2-(4-((1S)-2-(5-cloro-2-methylphenyl)-1-methylethylamino)-2-oxo-1,2-dihydropyridin-3-yl)-6-(2-pyrrolidin-1-ylethyl)-6,7-dihydroimidazo[4,5-f]isoindol-5(3H)-one 

Relevant academic research and scientific papers

METHOD OF PRODUCING IODIZING AGENT, AND METHOD OF PRODUCING AROMATIC IODINE COMPOUND

A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.

Palladium-catalyzed sequential alkylation - Alkenylation reactions and their application to the synthesis of fused aromatic rings

The synthesis of fused aromatic carbocycles from aryl iodides and difunctional acceptors is outlined. This methodology is based on a palladium-catalyzed aromatic substitution followed by an intramolecular Heck sequence. Under the optimized conditions (Pd(OAc)2 (10 mol %), tri-2-furylphosphine (20-30 mol %), norbornene (2 equiv), Cs2CO3 (2 equiv), CH3CN, reflux), bromoenoates react with aryl iodides bearing numerous substituents (F, Cl, CF3, Me, etc.). The expanded description of our initial work as well as the use of polysubstituted aryl iodides is described.

STOICHIOMETRIC AND CATALYTIC OXIDATIVE IODINATION OF AROMATIC COMPOUNDS IN THE PRESENCE OF NITROGEN-CONTAINING OXIDIZING AGENTS IN AQUEOUS TRIFLUOROACETIC ACID

The conditions for oxidative monoiodination of benzene, halogenobenzenes, toluene, halogenotoluenes, and p-toluic acid in solvents based on trifluoroacetic acid were studied.Yields of the respective iodoarenes close to quantitative were obtained in systems containing 10-20 vol. percent of water in the solvent with equimolar amounts of alkali-metal metal iodides in relation to the substrate in the presence of stoichiometric (under anaerobic conditions) or catalytic (in the presence of oxygen or air) amounts of alkali-metal nitrates.The analogous reactions with nitrites can only be conducted under aerobic conditions.These iodinating systems are compared with systems based on acetic acid containing iodine and mixtures of sulfuric and nitric acids.The conditions for the iodination of toluene and for the transformations of the obtained iodotoluenes in the presence of nitrogen-containing oxidizing agents in trifluoroacetic acid solutions were studied in detail.It was shown that p-iodotoluene undergoes ipso-nitrodeiodination to a significant degree under these conditions.It is supposed that the iodinating agent in the investigated systems is trifluoroacetyl hypoiodite.Data on the assignment of the PMR spectra of the synthesized isomeric nitroiodotoluenes and chloroiodotoluenes by a simple additive method are given.