58966-34-0Relevant articles and documents
Large-steric-hindrance triarylmethane derivative and synthesis method thereof
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Paragraph 0055-0056, (2020/06/30)
The invention provides a large-steric-hindrance triarylmethane derivative which has a general formula as shown in a compound (1) which is described in the specification. In the general formula, R1 isa C1-C6 alkyl group or C1-C6 alkoxy group; R2 is a C1-C6 alkyl group or C1-C6 alkoxy group; R3 is a C1-C6 alkyl group; R4 is independently selected from hydrogen, a methyl group, a methoxy group, halogen, a halogen substituted methyl group, a phenyl group and a naphthyl group; R5 is independently selected from hydrogen, a methyl group, a methoxy group, halogen, a halogen substituted methyl group,a phenyl group and a naphthyl group; R6 is respectively independent hydrogen, a methyl group, a methoxy group, halogen, a halogen substituted methyl group, a phenyl group and a naphthyl group; and X is halogen. The method has the advantages of simple operation, cheap and easily available raw materials, and suitableness for mass production.
Secondary Amines as Renin Inhibitors
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Page/Page column 13, (2009/07/18)
The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
SECONDARY AMINES AS RENIN INHIBITORS
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Page/Page column 37-38, (2010/11/28)
The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.