58966-34-0Relevant articles and documents
Large-steric-hindrance triarylmethane derivative and synthesis method thereof
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Paragraph 0055-0056, (2020/06/30)
The invention provides a large-steric-hindrance triarylmethane derivative which has a general formula as shown in a compound (1) which is described in the specification. In the general formula, R1 isa C1-C6 alkyl group or C1-C6 alkoxy group; R2 is a C1-C6 alkyl group or C1-C6 alkoxy group; R3 is a C1-C6 alkyl group; R4 is independently selected from hydrogen, a methyl group, a methoxy group, halogen, a halogen substituted methyl group, a phenyl group and a naphthyl group; R5 is independently selected from hydrogen, a methyl group, a methoxy group, halogen, a halogen substituted methyl group,a phenyl group and a naphthyl group; R6 is respectively independent hydrogen, a methyl group, a methoxy group, halogen, a halogen substituted methyl group, a phenyl group and a naphthyl group; and X is halogen. The method has the advantages of simple operation, cheap and easily available raw materials, and suitableness for mass production.
SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS
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Page/Page column 36, (2014/02/16)
The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
Secondary Amines as Renin Inhibitors
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Page/Page column 13, (2009/07/18)
The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
Spiroindolinone Derivatives
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Page/Page column 17, (2009/07/10)
There are provided compounds of the formula and pharmaceutically acceptable salts and esters and enantiomers thereof wherein W, X, X′, Y, V, V′, A, B and R are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
SECONDARY AMINES AS RENIN INHIBITORS
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Page/Page column 37-38, (2010/11/28)
The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof
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Page column 135 - 136, (2010/11/29)
The present invention is to provide a compound of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optionally sub
Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
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, (2008/06/13)
Compounds of formula I: as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such compounds and methods of treatment are also included.