55687-91-7

Usage

InChI:InChI=1/C16H22N4O3/c1-16(2,21)13-11(22-3)6-9(7-12(13)23-4)5-10-8-19-15(18)20-14(10)17/h6-8,21H,5H2,1-4H3,(H4,17,18,19,20)

Upstream product

• 50-01-1 guanidine hydrochloride 
• 74731-75-2 (Z)-2-[4-(1-Hydroxy-1-methyl-ethyl)-3,5-dimethoxy-benzyl]-3-phenylamino-acrylonitrile 
• 33187-98-3 3,5-dimethoxy-4-(methoxycarbonyl)benzaldehyde 
• 16849-68-6 dimethyl 2,6-dimethoxyterephthalate 
• 55687-80-4 methyl 2,6-dimethoxy-4-(α,α-diethoxymethyl)benzoate 
• 55687-94-0 4-(1-hydroxy-1-methylethyl)-3,5-dimethoxybenzaldehyde 
• 74731-73-0 (Z)-2-[4-(1-Hydroxy-1-methyl-ethyl)-3,5-dimethoxy-benzyl]-3-morpholin-4-yl-acrylonitrile 
• 55687-93-9 4-(1-hydroxy-1-methyl-ethyl)-3,5-dimethoxy-α-(methoxy-methylene)-hydrocinnamic acid nitrile 
• 55687-90-6 2-[4-(4-acetylamino-2-amino-pyrimidin-5-ylmethyl)-2,6-dimethoxy-phenyl]-propan-2-ol 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of C(4')-substituted analogs of trimethoprim

A series of 2,4-diamino-5-(3,5-dimethoxybenzyl)-pyrimidines substitute at C(4') of the benzene ring with a functionalized carbon atom was synthesized. The target substances were tested for inhibition of dihydrofolate reductases from E. coli and rat liver,

2,4-Diamino-5-benzylpyrimidines

2,4-Diamino-5-benzylpyrimidines characterized by the formula SPC1 Wherein R1, R2, A1, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they block bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.