55687-46-2

Upstream product

• 55687-40-6 methyl α-(2,4-diamino-5-pyrimidinyl)-2,6-dimethoxy-p-toluate 
• 55687-43-9 methyl 4-(2-cyano-3-morpholinoallyl)-2,6-dimethoxybenzoate 
• 55687-39-3 methyl 4-(3-anilino-2-cyanoallyl)-2,6-dimethoxybenzoate 
• 16849-68-6 dimethyl 2,6-dimethoxyterephthalate 
• 33187-98-3 3,5-dimethoxy-4-(methoxycarbonyl)benzaldehyde 
• 67-63-0 isopropyl alcohol 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of C(4')-substituted analogs of trimethoprim

A series of 2,4-diamino-5-(3,5-dimethoxybenzyl)-pyrimidines substitute at C(4') of the benzene ring with a functionalized carbon atom was synthesized. The target substances were tested for inhibition of dihydrofolate reductases from E. coli and rat liver,

2,4-Diamino-5-benzylpyrimidines

2,4-Diamino-5-benzylpyrimidines characterized by the formula SPC1 Wherein R1, R2, A1, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they block bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.