332037-96-4Relevant academic research and scientific papers
Design, synthesis, biological activities and 3D-QSAR of new N,N′-diacylhydrazines containing 2,4-dichlorophenoxy moieties
Sun, Guo-Xiang,Sun, Zhao-Hui,Yang, Ming-Yan,Liu, Xing-Hai,Ma, Yi,Wei, Yun-Yang
, p. 14876 - 14891 (2014/01/17)
A series of new N,N′-diacylhydrazine derivatives were designed and synthesized. Their structures were verified by 1H-NMR, MS and elemental analysis. The herbicidal activities and plant growth regulating activity of these N,N′-diacylhydrazines were evaluated. The herbicidal activity results showed that most of these N,N′-diacyl-hydrazines showed excellent in vivo activities against Echinochloa crus-galli, Digitaria sanguinalis, Brassica napus, Amaranthus retroflerus. Most of them exhibited higher herbicidal activities against dicotyledonous weeds than monocotyledonous weeds. To further investigate the structure-activity relationship, comparative molecular field analysis (CoMFA) was performed on the basis of herbicidal activity data. Both the steric and electronic field distributions of CoMFA are in good agreement in this work.
Design, Synthesis, Biological Activities, and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2-(2,4-dichlorophenoxy)propane Moiety
Liu, Xing-Hai,Pan, Li,Ma, Yi,Weng, Jian-Quan,Tan, Cheng-Xia,Li, Yong-Hong,Shi, Yan-Xia,Li, Bao-Ju,Li, Zheng-Ming,Zhang, Yong-Gang
, p. 689 - 694 (2012/05/19)
A series of new N,N'-diacylhydrazine derivatives were synthesized efficiently under microwave irradiation. Their structures were characterized by 1H NMR, MS, and elemental analysis. Various biological activities of these compounds were tested. Most of them exhibited higher herbicidal activities against dicotyledonous weeds than monocotyledonous weeds. In addition, favorable in vivo fungicidal activities were also found of these compounds against Cladosporium cucumerinum, Corynespora cassiicola, Sclerotinia sclerotiorum(Lib.)de Bary, Erysiphe cichoracearum, and Colletotrichum orbiculare (Berk aLMont) Arx. All compounds displayed excellent plant growth regulatory activities: 100% inhibition was achieved against the radicle growth of cucumber. To further investigate the structure-activity relationship, comparative molecular field analysis was performed on the basis of herbicidal activity data, resulting in a statistically reliable model with good predictive power (r2=0.913, q2=0.556). Based on the calculation, five additional novel compounds were designed and synthesized. Satisfyingly, compound 4u displayed excellent herbicidal activity (94.7%) at 1500g/ha, although it is less active than 2,4-D. Meanwhile, this compound also exhibited good fungicidal activity against C. orbiculare (Berk aLMont) Arx (82.16%). A series of new N,N'-diacylhydrazine derivatives were synthesized under microwave irraiation. Various biological (herbicidal, plant growth regulatory, fungicidal) activities of these compounds were tested. The structure-activity relationship (CoMFA) was performed.
