332386-66-0

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 18065-05-9 1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone 
• 333796-77-3 (E)-1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-3-[3,4,5-tris(benzyloxy)phenyl]propenone 
• 333796-78-4 5,7-dibenzyloxy-2-[3,4,5-tris(benzyloxy)phenyl]-2H-chromene 
• 100-39-0 benzyl bromide 
• 6137-86-6 3,4,5-tribenzyloxybenzaldehyde 
• 70424-94-1 methyl 3,4,5-tris(benzyloxy)benzoate 
• 79831-88-2 3,4,5-tribenzyloxybenzyl alcohol 
• 99-24-1 methyl galloate 

Relevant academic research and scientific papers

Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents

Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I) wherein R1 through R11 are defined herein. Preferred R4 moieties are selected from O, S, NH and CH2, and in exemplary compounds, R4 is O and R5 is a tri-substituted aroyloxy substituent, such as a 3,4,5-substituted benzoyloxy group. Pharmaceutical compositions are provided as well, as are methods of chemotherapy and chemoprevention.

Synthesis of a 3,4,5-trimethoxybenzoyl ester analogue of epigallocatechin-3-gallate (EGCG): A potential route to the natural product green tea catechin, EGCG

matrix presented The synthesis of a trimethoxybenzoyl ester (D-ring) analogue of epigallocatechin-3-gallate (EGCG) is described. The versatile synthesis route can be used to synthesize A, B, and D ring analogues of EGCG and involves a key cyclization of t