332386-70-6

Upstream product

• 79831-88-2 3,4,5-tribenzyloxybenzyl alcohol 
• 970-73-0 epigallocatechin 
• 332386-57-9 (1R,2R)-3-[2,4-Bis-benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(3,4,5-tris-benzyloxy-phenyl)-propane-1,2-diol 
• 332386-55-7 (E)-3-[2,4-bis(benzyloxy)-6-(tert-butyldimethylsilyloxy)phenyl]-1-[3,4,5-tris(benzyloxy)phenyl]propene 
• 1027171-15-8 3,5-Bis-benzyloxy-2-[(4R,5R)-2-ethoxy-5-(3,4,5-tris-benzyloxy-phenyl)-[1,3]dioxolan-4-ylmethyl]-phenol 
• 332386-59-1 (+)-(1R,2R)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3,4,5-tris(benzyloxy)phenyl]propane-1,2-diol 
• 332386-61-5 (E)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-[3,4,5-tris(benzyloxy)phenyl]-propene 
• 70424-94-1 methyl 3,4,5-tris(benzyloxy)benzoate 
• 332386-67-1 ethyl (E)-3,4,5-tris(benzyloxy)cinnamate 
• 332386-68-2 (E)-3-[3,4,5-tris(benzyloxy)phenyl]prop-2-en-1-ol 
• 6137-86-6 3,4,5-tribenzyloxybenzaldehyde 
• 915954-70-0 [2-(3,5-bis-benzyloxy-2-iodo-phenoxy)-1-bromomethyl-2-(3,4,5-tris-benzyloxy-phenyl)-ethoxy]-tert-butyl-dimethyl-silane 
• 915954-69-7 1-(3,5-bis-benzyloxy-2-iodo-phenoxy)-3-bromo-1-(3,4,5-tris-benzyloxy-phenyl)-propan-2-ol 
• 915954-68-6 2-[(3,5-bis-benzyloxy-2-iodo-phenoxy)-(3,4,5-tris-benzyloxy-phenyl)-methyl]-oxirane 

Downstream Products

• 332386-78-4 (S)-5,7-Bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-one 
• 332386-73-9 (+)-(2S,3S)-cis-5,7-bis(benzyloxy)-2-[3,4,5-tris(benzyloxy)phenyl]chroman-3-ol 
• 332386-76-2 Bn-(+)-EGCG 
• 3371-27-5 (-)-gallocatechin 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis

Green tea and its natural components are known for their usefulness against a variety of diseases. In particular, the activity of main catechin Epigallocatechin gallate (EGCG) against Dual-specificity tyrosine-(Y)-phosphorylation Regulated Kinase-1A (DYRK1A) has been reported; here we are showing a structure–activity relationship (SAR) for EGCG against this molecular target. We have studied the influence of all four rings on the activity and the nature of its absolute geometry. This work has led to the identification of the more potent and stable trans fluoro-catechin derivative 1f (IC50 = 35 nM). This molecule together with a novel delivery method showed good efficacy in vivo when tested in a validated model of multiple sclerosis (EAE).

METHOD FOR PRODUCING FLAVAN DERIVATIVE

The present invention provides a method for producing flavan derivatives having various substituent groups with controlling the stereochemistry. The method of the present invention includes the steps of: hydratively condensing a phenol compound expressed

General and convenient approach to flavan-3-ols: Stereoselective synthesis of (-)-gallocatechin

General synthetic route to flavan-3-ols was developed. Union of two fragments was accomplished by an efficient three-step protocol, enabling the stereoselective synthesis of (-)-gallocatechin. Copyright

Enantioselective synthesis of epigallocatechin-3-gallate (EGCG), the active polyphenol component from green tea.

[reaction: see text]. Enantioselective synthesis of epigallocatechin-3-gallate (EGCG, 3b), the active polyphenol component from green tea, has been achieved by using a stereospecific cyclization of the Sharpless asymmetric dihydroxylation product 7c as the key step.