3324-54-7

Upstream product

• 63104-44-9 dimethyl 2,2-di(prop-2-ynyl)malonate 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 
• 3355-31-5 1-chloro-3-phenyl-2-propyne 
• 16900-65-5 1,7-diphenyl-4,4-bis(ethoxycarbonyl)hepta-1,6-diyne 

Downstream Products

• 1451053-27-2 (Z)-5-benzylidene-3-(3-phenylprop-2-ynyl)dihydrofuran-2(3H)-one 
• 1451053-24-9 (Z)-5-benzylidene-3-(3-phenylprop-2-ynyl)dihydrofuran-2(3H)-one 
• 77670-54-3 (Z)-3-(phenylprop-2-ynyl)-5-phenylmethylidene-γ-butyrolactone 
• 77670-56-5 6-Phenyl-3-(3-phenyl-prop-2-ynyl)-3,4-dihydro-pyran-2-one 
• 77670-55-4 5-[1-Phenyl-meth-(E)-ylidene]-3-(3-phenyl-prop-2-ynyl)-dihydro-furan-2-one 

Relevant academic research and scientific papers

Pd(ii)-SDP-catalyzed enantioselective 5-exo-dig cyclization of γ-alkynoic acids: Application to the synthesis of functionalized dihydofuran-2(3H)-ones containing a chiral quaternary carbon center

The Pd(ii)-SDP-catalyzed first enantioselective intramolecular cyclization of α,α-disubstituted γ-alkynoic acids is described. This 5-exo-dig cyclization afforded dihydrofuran-2(3H)-ones bearing a chiral quaternary carbon center in excellent yields with e

Cyclisation of Acetylenecarboxylic Acid. Synthesis of γ-Methylenebutyrolactones

Various γ-exo-methylenebutyrolactones have been synthesized in excellent yield by the cyclisation of acetylenecarboxylic acids in the presence of a catalytic amount of mercury(II) oxide.Cyclisation of terminal acetylene compounds proceeded regioselectively to give γ-exo-methylenebutyrolactones as the sole product.Disubstituted acetylenes also gave the (Z)-configurational enol lactone, but small amounts of an (E)-isomer of a γ-exo-enol lactone and a δ-lactone (α-pyrone) were also formed.Spectral properties and stereochemistry of the exo-enol lactones are also discussed.