537-21-3 Usage
Uses
PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
Clinical Use
Malaria chemoprophylaxis
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine.
Metabolism
Proguanil is metabolised in the liver to the active
metabolite, cycloguanil, and to p-chlorophenylbiguanide
which is inactive, mainly by cytochrome P450, CYP
2C19 and slightly by CYP 3A4. Unlike proguanil and
p-chlorophenylbiguanide, cycloguanil is not concentrated
in erythrocytes so concentrations of cycloguanil in
plasma and whole blood are similar. About 40-60% of
a dose of proguanil is excreted in the urine, 60% of this
as the unchanged drug, 30% as cycloguanil, and 8% as
p-chlorophenylbiguanide. About 10% of a dose is excreted
in the faeces.
Check Digit Verification of cas no
The CAS Registry Mumber 537-21-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 537-21:
(5*5)+(4*3)+(3*7)+(2*2)+(1*1)=63
63 % 10 = 3
So 537-21-3 is a valid CAS Registry Number.
InChI:InChI=1S/C11H15Cl2N5/c1-6(2)16-10(14)18-11(15)17-7-3-4-8(12)9(13)5-7/h3-6H,1-2H3,(H5,14,15,16,17,18)
