33240-96-9

Basic information

• Product Name: 3-NITROANILINE HYDROCHLORIDE
• Synonyms: 3-nitro-benzenaminmonohydrochloride;m-nitroanilinehydrochloride;m-nitro-anilinmonohydrochloride;3-NITROANILINE HYDROCHLORIDE;3-nitroanilinium chloride;3-NitroanilineHCl
• CAS NO: 33240-96-9
• Molecular Formula: C₆H₇N₂O₂*Cl
• Molecular Weight: 174.58
• EINECS: 251-421-3
• Mol File: 33240-96-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 225-227 °C
• Boiling Point: 307°C at 760 mmHg
• Flash Point: 139.5°C
• Appearance: /
• Vapor Pressure: 0.000745mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 3-NITROANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITROANILINE HYDROCHLORIDE(33240-96-9)
• EPA Substance Registry System: 3-NITROANILINE HYDROCHLORIDE(33240-96-9)

Safety Data

• RTECS: BY7370000
• Hazardous Substances Data: 33240-96-9(Hazardous Substances Data)

Usage

General Description

3-NITROANILINE HYDROCHLORIDE is a chemical compound that is primarily used in the manufacturing of dyes, pigments, and pharmaceuticals. It is a derivative of aniline in which a nitro group is substituted for one of the hydrogen atoms. The hydrochloride salt form of 3-nitroaniline is a yellow crystalline solid that is soluble in water. It is classified as a hazardous substance and can cause irritation to the skin, eyes, and respiratory system if not handled properly. Additionally, it is also considered to be a potential environmental hazard and should be disposed of carefully according to regulations.

InChI:InChI=1/C6H6N2O2.ClH/c7-5-2-1-3-6(4-5)8(9)10;/h1-4H,7H2;1H

Upstream product

• 618-46-2 m-Chlorobenzoyl chloride 
• 99-09-2 3-nitro-aniline 
• 67-56-1 methanol 
• 934-53-2 cumenyl chloride 
• 40473-10-7 2-chloro-2-(3'-chlorophenyl)propane 
• 13240-60-3 3-(2-Chloro-2-propyl)toluene 
• 42325-37-1 4-(α-chloro-isopropyl)-biphenyl 
• 14276-97-2 1-chloro-4-(α-chloro-isopropyl)-benzene 
• 102-38-5 N-(3-nitrophenyl)formamide 
• 122-28-1 N-(3-nitrophenyl)acetanilide 
• 99-65-0 meta-dinitrobenzene 
• 52038-84-3 3-chlorophenyl methyl phosphonochloridothioate 
• 27976-53-0 4-methoxyphenyl methyl phosphonochloridothioate 
• 14410-08-3 4-methylphenyl methyl phosphonochloridothioate 

Downstream Products

• 71319-72-7 N-(3-nitrophenyl)ethane-1,2-diamine 
• 64782-02-1 1,2-Dichlor-cyclopenten-(1)-trion-(3,4,5)-<3-nitro-phenylhydrazon)-(4)> 
• 100958-73-4 benzo[d]thiazole-2,7-diamine 
• 89793-81-7 7-nitrobenzo[d]thiazol-2-amine 
• 920941-20-4 C₁₁H₉N₃O₄ 
• 122-28-1 N-(3-nitrophenyl)acetanilide 
• 1430208-89-1 (1-(3-nitrophenyl)-3-(2-(trifluoromethyl)phenyl)guanidine) 
• 58759-63-0 5-nitro-2-mercaptobenzothiazole 

Relevant articles and documents

Synthesis and evaluation of some benzothiazole derivatives as antidiabetic agents

Objective: The objective of the present research investigation involves synthesis and biological evaluation of antidiabetic activity of benzothiazole derivatives. Methods: A novel series of benzothiazole derivatives 7(a-l) were synthesised and synthesised compounds were characterised for different physical and chemical properties like molecular formula, molecular weight, melting point, percentage yield, Rf value, IR,1HNMR,13CNMR and mass spectroscopy. The newly synthesised benzothiazole derivatives were subsequently assayed in vivo to investigate their hypoglycemic activity by the alloxan-induced diabetic model in rats. Results: All the synthesised derivatives showed significant biological efficacy. The compound 7d at 350 mg/kg exerted maximum glucose lowering effects whereas 7c showed minimum glucose lowering effects. All the compounds were effective, and experimental results were statistically significant at p0.01 and p0.05 level. Conclusion: From the results, it is clear that compound 7d demonstrated potent anti-diabetic activity and would be of better use in drug development to combat the metabolic disorder in future.

A facile and efficient method for the selective deacylation of N-arylacetamides and 2-chloro-Narylacetamides catalyzed by SOCl2

Thionyl chloride efficiently and selectively promoted the deacylation of N-arylacetamides and 2-chloro-N-arylacetamides, under anhydrous conditions, without effecting the ester group, aminosulfonyl group, or benzyloxyamide group. This method, which has been successfully applied to a variety of substrates including different N-arylacetamides and 2-chloro-N-arylacetamides, has the attractive advantages of inexpensive reagents, satisfactory selectivity, excellent yields, short reaction time, and convenient workup. This new method can probably be used to selectively deacylate between aromatic amides and alkyl amides. Springer Science+Business Media B.V. 2011.

Iron-catalyzed selective reduction of nitro compounds to amines

An efficient reduction of the nitro group with a catalytic amount of Fe(acac)3 and TMDS in THF at 60 °C affording the corresponding amine is described.