102-38-5

Usage

Uses

Used in Chemical Synthesis:
3-Nitroformanilide is used as an intermediate compound in the synthesis of various chemical products. Its role in the production process is crucial for creating a range of end products.
Used in Dye and Pigment Production:
3-Nitroformanilide is employed as a key component in the manufacturing of dyes and pigments. Its chemical properties contribute to the color and stability of these products, making it an essential part of the production process.
Used in Pharmaceutical Industry:
3-Nitroformanilide is used as a building block in the development of pharmaceutical compounds. Its reactivity and structural characteristics make it a valuable asset in the synthesis of new drugs and medications.
Used in Research and Development:
In the scientific community, 3-Nitroformanilide is utilized in research and development settings. It serves as a model compound for studying the properties and reactions of nitro compounds, furthering our understanding of organic chemistry and its applications.

InChI:InChI=1/C7H6N2O3/c10-5-8-6-2-1-3-7(4-6)9(11)12/h1-5H,(H,8,10)

Upstream product

• 110-86-1 pyridine 
• 64-18-6 formic acid 
• 99-09-2 3-nitro-aniline 
• 103-70-8 Formanilid 
• 2008-59-5 1-isocyano-3-nitrobenzene 
• 150760-95-5 formic acid cyanomethyl ester 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 122-51-0 orthoformic acid triethyl ester 
• 109-94-4 formic acid ethyl ester 
• 77287-34-4 formamide 
• 50-00-0 formaldehyd 
• 107-31-3 Methyl formate 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 6262-24-4 formic acid-(3-amino-anilide) 
• 15999-30-1 (3-nitro-phenyl)-carbonimidic acid dichloride 
• 2008-59-5 1-isocyano-3-nitrobenzene 
• 99-09-2 3-nitro-aniline 
• 64-18-6 formic acid 
• 333793-39-8 N-(1-methyl-2-oxo-propyl)-N-(3-nitrophenyl)formamide 
• 74702-17-3 C₆H₄(NO₂)N(CHO)SCFCl₂ 
• 333793-43-4 N-(3-nitrophenyl)-N-(2-oxo-propyl)-formamide 
• 1293333-51-3 N-(2,2-dibromovinyl)-N-(3-nitrophenyl)pivalamide 
• 1259119-43-1 C₁₂H₁₄N₂O₄ 
• 1374349-41-3 N-(⁽¹¹⁾C-methyl)-N-(3-nitrophenyl)formamide 
• 33240-96-9 3-nitroaniline hydrochloride 

Relevant academic research and scientific papers

Nano rod-shaped and reusable basic Al2O3 catalyst for N-formylation of amines under solvent-free conditions: A novel, practical and convenient 'NOSE' approach

An expeditious, simple, highly efficient, practical and green protocol for the N-formylation of alkyl/aryl amines and indole derivatives catalyzed by novel nano rod-shaped basic Al2O3 under solvent-free conditions has been developed. The catalyst is efficiently recycled up to the 5th run, an important point in the domain of green chemistry. The methodology provides cleaner conversion, shorter reaction times and high selectivity which makes the protocol attractive. The Royal Society of Chemistry 2012.

Nickel-(II)-Catalyzed N-Formylation and N-Acylation of Amines

A highly efficient protocol of Ni(II) metal complex, [Ni(quin)2], catalyzing N-formylation and N-acylation of amines with moderate to excellent yields, using N,N-dimethylformamide and N,N-dimethylacetamide in the presence of imidazole, is described here. The protocol shows broad substrate scope for aliphatic, aromatic, and heterocyclic amines.

Melamine trisulfonic acid-catalyzed N-formylation of amines under solvent-free conditions

A highly convenient method for N-formylation of amines via treatment by formic acid in the presence of melamine trisulfonic acid as a catalyst has been developed. This method showed improvements over previous reports in terms of yield, reaction time and chemoselectivity.

Neat formic acid: An excellent N-formylating agent for carbazoles, 3- alkylindoles, diphenylamine and moderately weak nucleophilic anilines

Neat formic acid alone efficiently N-formylates carbazoles, 3- alkylindoles, diphenylamine and even moderately weak nucleophilic anilines to furnish the corresponding N-formyl derivatives in 72-87% yields.

Carbon nanotube-gold nanohybrid catalyzed N-formylation of amines by using aqueous formaldehyde

The N-formylation of a variety of primary and secondary amines by using aqueous formaldehyde at room temperature in open air affords the corresponding formamides in excellent yield under the catalytic influence of a gold-carbon nanotube nanohybrid. The reaction is also marked by excellent chemoselectivity, low catalyst loading, and recyclability of the catalyst.

Nano-MgO: An efficient catalyst for the synthesis of formamides from amines and formic acid under MWI

Nano-MgO a basic catalyst was prepared by solution combustion technique. It was characterized by powder XRD, SEM, BET and TEM analyses. It was used as a catalyst for the study of microwave-assisted N-formylation of various aromatic and alkyl amines with formic acid under solvent-free conditions. Nano-MgO showed excellent catalytic properties and the reactions went to completion, within 1-2 min to give products in high yield (90-98%). The catalyst is recoverable quantitatively and re-cycled with almost consistent activity. This new nano catalyst has the advantages of higher yield, lower cost, reduced environmental hazards, and the procedure is highly convenient. Graphical Abstract: Nano-MgO was prepared and characterized by PXRD, SEM, BET and TEM analyses. It was used for the study of microwave-assisted N-formylation of various amines with formic acid under solvent-free condition.

A very simple and highly efficient procedure for N-formylation of primary and secondary amines at room temperature under solvent-free conditions

N-Formylation of primary and secondary amines has efficiently been carried out at room temperature in excellent yields by using catalytic amount of sodium formate in formic acid under solvent-free conditions. The process is remarkably simple and environmentally benign.

A convenient procedure for the formylation of amines and alcohols using cyanomethyl formate

A simple metyod for the direct formylation of amines using cyanomethyl formate is described. The formylation succeeds in moderate to high yields under mild and neutral conditions. Thus, formamides 2a-f, 2i-m are obtained at room temperature. A chemoselective N-formylation is achieved in the case of ethanolamine. The formylation of nitroanilines and the O-formylation of alcohols only succeeds in the presence of a catalytic amount of imidazole leading to 2g,h and 3a-e, respectively.

Solvent- and catalyst-free N-formylations of amines at ambient condition: Exploring the usability of aromatic formates as N-formylating agents

A solvent- and catalyst-free N-formylation protocol has been developed for amines (1s–21s) where aromatic formates (1r–6r) were used as the N-formylating agents. The amine substrates include both primary and secondary aromatic amines (1s–19s) as well as aliphatic amine (20s) and a primary amide (21s). Structures of both the aromatic formate and amine components strongly influenced the rate of the reaction and yield of the N-formamide products. The reaction condition is mild and easy to operate. This protocol can be done smoothly under ambient conditions and gives high yield of formamide products. Furthermore, the present method cannot be applied for the formylation of thiol group (22s). This signifies its possible use for the chemoselective N-formylation of amine in the presence of thiol functionality.

A green protocol for the N-formylation of amines using molybdate sulfuric acid as a reusable solid catalyst

A novel and efficient method for the N-formylation of amines via the reaction of orthoformates and amines is developed. The reactions are mediated by a catalytic amount of molybdate sulfuric acid as a heterogeneous solid acid.