33263-43-3

Basic information

• Product Name: 4-Chloro-3-pyridinesulfonamide
• Synonyms: 4-CHLORO-3-PYRIDINESULFAMIDE;4-CHLORO-3-PYRIDINESULFONAMIDE;4-CHLORO-3-PYRIDINESULFONAMIDE HYDROCHLORIDE;4-CHLORO-3-PYRIDINESULPHONAMIDE;4-CHLORO-PYRIDINE-3-SULFONIC ACID AMIDE;4-CHLOROPYRIDINE-3-SULPHONAMIDE;4-CHLOROPYRIDINE-3-SULFONAMIDE;4-CHOROPYRIDINE-3-SULPHONAMIDE
• CAS NO: 33263-43-3
• Molecular Formula: C5H5ClN2O2S
• Molecular Weight: 192.62
• EINECS: 251-434-4
• Product Categories: SULFONAMIDE;Pyridines
• Mol File: 33263-43-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 150-155 °C
• Boiling Point: 380.4 °C at 760 mmHg
• Flash Point: 183.9 °C
• Appearance: off-white to light beige powder
• Density: 1.558 g/cm³
• Vapor Pressure: 5.46E-06mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.01±0.60(Predicted)
• Water Solubility: soluble
• CAS DataBase Reference: 4-Chloro-3-pyridinesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-pyridinesulfonamide(33263-43-3)
• EPA Substance Registry System: 4-Chloro-3-pyridinesulfonamide(33263-43-3)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 36/37
• RIDADR: 2811
• PackingGroup: III
• Hazardous Substances Data: 33263-43-3(Hazardous Substances Data)

Usage

Chemical Properties

off-white to light beige powder

Uses

4-Chloro-3-pyridinesulfonamide is a building block that has been used as a reactant for the preparation of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives as inhibitors of four isoforms of zinc enzyme carbonic anhydrase.

InChI:InChI=1/C5H5ClN2O2S/c6-4-1-2-8-3-5(4)11(7,9)10/h1-3H,(H2,7,9,10)

Upstream product

• 626-64-2 pyridin-4-ol 
• 51498-37-4 4-hydroxypyridine-3-sulfonic acid 
• 33263-44-4 4-chloro-pyridine-3-sulfonyl chloride 

Downstream Products

• 76254-94-9 4-Hexylamino-pyridine-3-sulfonic acid amide 
• 73743-01-8 4-(1-Ethynyl-cyclohexylamino)-pyridine-3-sulfonic acid amide 
• 76255-09-9 4-(3-Methyl-benzylamino)-pyridine-3-sulfonic acid amide 
• 76255-11-3 4-Phenethylamino-pyridine-3-sulfonic acid amide 
• 56211-40-6 torasemide 
• 76254-78-9 4-methylaminopyridine-3-sulfonamide 
• 76255-08-8 4-Benzylamino-pyridine-3-sulfonic acid amide 
• 76255-10-2 4-(3-Chloro-benzylamino)-pyridine-3-sulfonic acid amide 
• 76255-12-4 4-(Benzhydryl-amino)-pyridine-3-sulfonic acid amide 
• 75903-62-7 4-aminopyridine-3-sulfonamide 
• 76255-03-3 (4-(cyclohexylamino)pyrid-3-yl)sulfonamide 
• 73743-02-9 3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-3'-sulfonic acid amide 
• 1170558-67-4 (S)-piperidine-3-sulfonamide hydrochloride 
• 1170558-67-4 (R)-piperidine-3-sulfonamide hydrochloride 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF HIGHLY PURE TORSEMIDE

The present invention provides a novel process for the preparation of highly pure torsemide [1] by reacting of 4-m-tolylamino-3-pyridinesulfonamide [2] with phenyl isopropylcarbamate in the presence of lithium base (F I, II). The present invention also provides a novel intermediate - torsemide lithium, also in hydrate or solvate form - which is a stable, solid compound, and may be simply isolated from the reaction mixture to give after acidification practically pure torsemide [1] without further purification steps.

3-(Alkylamino)-4H-pyrido-1,2,4-thiadiazine 1,1-Dioxides as Powerful Inhibitors of Insulin Release from Rat Pancreatic B-Cells: A New Class of Potassium Channel Openers?

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