33265-78-0Relevant academic research and scientific papers
Transformation of 4-substituted tetrahydro-pyrrolobenzodiazepines in a three-component reaction with methyl propiolate and indole
Voskressensky,Borisova,Babakhanova,Titov,Chervyakova,Novikov,Butin,Khrustalev,Varlamov
, p. 1785 - 1794 (2014/05/06)
The three-component reaction of 4-phenyl-, p-methoxyphenyl-, and thienylpyrrolo[1,2-a][1,4]benzo-diazepines with methyl propiolate and indole in dichloromethane proceeds through opening of the diazepine ring. The major transformation products isolated are substituted pyrroles, namely, 1-(2-aminomethylphenyl)-5-(arylmethyl)-2-(indol-1(3)-yl)pyrroles and 1-(2-aminomethylphenyl)-2-aryl-(indol-3-yl)-methylpyrroles.
Synthesis of pyrrolo[1,2-a][1,6]benzodiazonines from pyrrolo[1,2-a][1,4] benzodiazepines and alkynes containing electron-acceptor substituents
Voskressensky,Borisova,Babakhanova,Chervyakova,Titov,Butin,Nevolina,Khrustalev,Varlamov
, p. 1024 - 1032 (2013/10/22)
It has been established that the reaction of pyrrolo[1,2-a][1,4] benzodiazepines with activated alkynes gives pyrrolo[1,2-a][1,6]benzodiazonines as the products of diazepine ring expansion. In the case of pyrrolo[1,2-a][1,4] benzodiazepine, substituted wi
