33266-96-5Relevant academic research and scientific papers
Synthesis method and application of 2-amino-1-(4-chlorphenyl) propane-1-ol
-
Paragraph 0009; 0033; 0035; 0038; 0040; 0043; 0045; ..., (2021/11/21)
The invention relates to a method for synthesizing a hexythiazox key intermediate and application of the hexythiazox key intermediate. The synthesis method comprises the following steps: 1) carrying out oxidation reaction on 1-(4-chlorphenyl) propyl-1-ene-2-yloxytrimethylsilane and m-chloroperoxybenzoic acid to generate an intermediate I; 2) adding K2CO3 into the intermediate I, and hydrolyzing to obtain 1-(4-chlorphenyl)-1-hydroxypropane-2-one; 3) adding TiCI4/NH4CL into 1-(4-chlorphenyl)-1-hydroxypropane-2-one, and carrying out a reaction to obtain an intermediate II; and 4) adding sodium cyanoborohydride into the intermediate II, and carrying out reduction to obtain 2-amino-1-(4-chlorphenyl) propane-1-ol. According to the invention, the prepared2-amino-1-(4-chlorphenyl) propane-1-ol is as high as 95.8% in yield, low in cost, as high as 98.5% in purity and good in quality; and the 2-amino-1-(4-chlorphenyl) propane-1-ol prepared by the method disclosed by the invention is used for preparing hexythiazox.
Switching regioselectivity in crossed acyloin condensations between aromatic aldehydes and acetaldehyde by altering n -heterocyclic carbene catalysts
Jin, Ming Yu,Kim, Sun Min,Han, Hogyu,Ryu, Do Hyun,Yang, Jung Woon
supporting information; experimental part, p. 880 - 883 (2011/05/02)
An unprecedented high level of regioselectivities (up to 96%) in the intermolecular crossed acyloin condensations of various aromatic aldehydes with acetaldehyde was realized by an appropriate choice of N-heterocyclic carbene catalysts.(Figure Presented)
Mechanism and scope of the cyanide-catalyzed cross silyl benzoin reaction
Linghu, Xin,Bausch, Cory C.,Johnson, Jeffrey S.
, p. 1833 - 1840 (2007/10/03)
In this work, cross silyl benzoin addition reactions between acylsilanes (1) and aldehydes (2) catalyzed by metal cyanides are described. Unsymmetrical aryl-, heteroaryl-, and alkyl-substituted benzoin adducts can be generated in moderate to excellent yie
Cross silyl benzoin additions catalyzed by lanthanum tricyanide
Bausch, Cory C.,Johnson, Jeffrey S.
, p. 4283 - 4285 (2007/10/03)
From a screen of (cyanide)metal complexes, an improved catalyst for the cross silyl benzoin addition was discovered. Several M(CN)3 complexes (M = Ce, Er, Sm, Y, Yb, La) were evaluated and lanthanum tricyanide was identified as the optimal cata
Ion exchange resin-mediated hydrolytic cleavage of α-nitroepoxides. Simple one-pot synthesis of α-hydroxyketones
Chakraborty,Das,Ranu
, p. 1523 - 1528 (2007/10/02)
α-Nitroepoxides are cleaved in an aqueous suspension with dowex-50 to furnish α-hydroxyketones in excellent yields.
