332850-65-4

Basic information

• Product Name: C₁₄H₁₁ClN₄
• Synonyms: C₁₄H₁₁ClN₄
• CAS NO: 332850-65-4
• Molecular Weight: 270.721
• Mol File: 332850-65-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₁ClN₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₁ClN₄(332850-65-4)
• EPA Substance Registry System: C₁₄H₁₁ClN₄(332850-65-4)

Safety Data

• Hazardous Substances Data: 332850-65-4(Hazardous Substances Data)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 18590-76-6 2-(2-chlorophenyl)-4(3H)-quinazolinethione 
• 4765-50-8 2-(2-chlorophenyl)quinazolin-4(3H)-one 
• 13324-80-6 2-(2-chlorophenyl)-1,2-dihydro-4(3H)-quinazolinone 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 1448068-42-5 C₁₅H₁₀ClN₅ 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 5-Phenyl-[1,2,4] triazolo[4,3-c]quinazolin-3-amines

In the present study we describe the syntheses and anticonvulsant activity evaluation of 5-phenyl-[1,2,4]triazolo[4,3-c]quinazolin-3-amine derivatives. Their anticonvulsant activity and neurotoxicity were evaluated by the maximal electroshock seizure test (MES) and the rotarod test, respectively. The majority of the compounds prepared were effective in the MES screens at a dose level of 100 mg/kg. Of these compounds, the most promising was compound 8h, which showed an ED50 value of 27.4 mg/kg and a protective index (PI) value of 5.8. These values were superior to those provided by valproate (ED50 and PI values of 272 and 1.6, respectively) in the MES test in mice. As well as its anti-MES efficacy, the potencies of compound 8h against seizures induced by pentylenetetrazole and thiosemicarbazide were also established, with the results suggesting that the GABAergic system-mediated mechanisms might be involved in its anticonvulsant activity. Copyright