4765-50-8

Basic information

• Product Name: 4(1H)-Quinazolinone, 2-(2-chlorophenyl)-
• CAS NO: 4765-50-8
• Molecular Formula: C14H9ClN2O
• Molecular Weight: 256.691
• Mol File: 4765-50-8.mol
• Article Data: 63

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinazolinone, 2-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinazolinone, 2-(2-chlorophenyl)-(4765-50-8)
• EPA Substance Registry System: 4(1H)-Quinazolinone, 2-(2-chlorophenyl)-(4765-50-8)

Safety Data

• Hazardous Substances Data: 4765-50-8(Hazardous Substances Data)

Upstream product

• 150614-25-8 2,2'-di(2-chlorophenyl)-3,3'-bis(1,2,3,4-tetrahydroquinazoline)-4,4'-dione 
• 89-98-5 2-chloro-benzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 118-92-3 anthranilic acid 
• 609-66-5 2-chlorobenzamide 
• 95-49-8 2-methylchlorobenzene 
• 118-48-9 isatoic anhydride 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 4001-73-4 2-Bromobenzamide 
• 2042-37-7 o-cyanobromobenzene 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 4765-49-5 N-(2-chloro-benzoyl)-anthranilic acid amide 
• 2136-89-2 2-chlorobenzotrichloride 
• 873-32-5 2-Chlorobenzonitrile 

Downstream Products

• 18590-76-6 2-(2-chlorophenyl)-4(3H)-quinazolinethione 
• 332850-65-4 C₁₄H₁₁ClN₄ 
• 1448068-42-5 C₁₅H₁₀ClN₅ 
• 59455-92-4 4-chloro-2-(2-chloro-phenyl)-quinazoline 

Relevant articles and documents

Metal-free catalyst for the visible-light-induced photocatalytic synthesis of quinazolinones

In the present work, we have developed a novel and environmentally friendly method for the synthesis of quinazolinones using fluorescein as a photocatalyst via a condensation reaction of o-aminobenzamides and aldehydes under visible light irradiation. In this protocol, neither toxic oxidants nor transition-metal catalysts were needed, and a series of quinazolinones could be obtained in high efficiencies. In addition, this reaction can be extended to gram levels and has a large potential of wide application in future industrialization.

Electro-oxidative cyclization: Access to quinazolinones: Via K2S2O8without transition metal catalyst and base

A K2S2O8-promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base. The key feature of this protocol is the utilization of K2S2O8 as an inexpensive and easy-to-handle radical surrogate that can effectively promote the reaction via a simple procedure, leading to the formation of nitrogen heterocycles via direct oxidative cyclization at room temperature in a one-pot procedure under constant current. Owing to the use of continuous-flow electrochemical setups, this green, mild and practical electrosynthesis features high efficiency and excellent functional group tolerance and is easy to scale up.

Br?nsted acid catalyzed synthesis of 2‐aryl‐quinazolinones via cyclization of 2‐aminobenzamide with benzonitriles in PEG

A simple and efficient Br?nsted acid catalyzed synthesis of 2‐aryl‐quinazolinones via cyclization of 2‐aminobenzamides with benzonitrile in PEG under metal and ligand‐free condition. All substituted benzonitriles were also well participated with the formation of the corresponding products in moderate to good yields.