332855-38-6

Basic information

• Product Name: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-methionyl-L-isoleucyl-L-phenylalanyl-, methyl ester
• CAS NO: 332855-38-6
• Molecular Formula: C32H52N4O7S
• Molecular Weight: 636.853
• Mol File: 332855-38-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-methionyl-L-isoleucyl-L-phenylalanyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-methionyl-L-isoleucyl-L-phenylalanyl-, methyl ester(332855-38-6)
• EPA Substance Registry System: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-methionyl-L-isoleucyl-L-phenylalanyl-, methyl ester(332855-38-6)

Safety Data

• Hazardous Substances Data: 332855-38-6(Hazardous Substances Data)

Upstream product

• 3845-64-5 tertbutoxycarbonyl-L-methionine N-hydroxysuccinimide ester 
• 64152-76-7 methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 2666-93-5 (S)-Leu-OMe 
• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 38155-19-0 L-phenylalanyl-L-leucine methyl ester 

Downstream Products

• 332855-44-4 N-formyl-Met-Ile-Phe-Leu-OMe 
• 332855-41-1 N-isopropylureido-Met-Ile-Phe-Leu-OMe 

Relevant articles and documents

Met-Ile-Phe-Leu derivatives: Full and partial agonists of human neutrophil formylpeptide receptors

The biological action of a series of Met-Ile-Phe-Leu analogues was analyzed on human neutrophils, to evaluate their ability to interact with formylpeptide receptors and to induce the related neutrophil responses. Three in vitro assays were carried out: receptor binding, chemotaxis and superoxide anion release. Our results demonstrate that formyl-Met-Ile-Phe-Leu derivatives act as more potent full agonists than formyl-Met-Leu-Phe, the tripeptide normally used as a model chemoattractant for the study of cell functions. On the other hand, the presence of N-ureidoisopropyl substituent in tetrapeptides imparts weak partial agonist properties. It has furthermore been demonstrated that the C-terminal methyl esterification or amination weakly influences the properties of tetrapeptide homologues. Finally, t-Boc-Met-Ile-Phe-Leu derivatives do not appear able to interact with formylpeptide receptors.