332855-41-1

Upstream product

• 18484-44-1 O-succinimidyl N-isopropylcarbamate 
• 332855-38-6 t-Boc-Met-Ile-Phe-Leu-OMe 
• 64152-76-7 methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate 
• 3845-64-5 tertbutoxycarbonyl-L-methionine N-hydroxysuccinimide ester 
• 38155-19-0 L-phenylalanyl-L-leucine methyl ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 2666-93-5 (S)-Leu-OMe 

Relevant academic research and scientific papers

Met-Ile-Phe-Leu derivatives: Full and partial agonists of human neutrophil formylpeptide receptors

The biological action of a series of Met-Ile-Phe-Leu analogues was analyzed on human neutrophils, to evaluate their ability to interact with formylpeptide receptors and to induce the related neutrophil responses. Three in vitro assays were carried out: receptor binding, chemotaxis and superoxide anion release. Our results demonstrate that formyl-Met-Ile-Phe-Leu derivatives act as more potent full agonists than formyl-Met-Leu-Phe, the tripeptide normally used as a model chemoattractant for the study of cell functions. On the other hand, the presence of N-ureidoisopropyl substituent in tetrapeptides imparts weak partial agonist properties. It has furthermore been demonstrated that the C-terminal methyl esterification or amination weakly influences the properties of tetrapeptide homologues. Finally, t-Boc-Met-Ile-Phe-Leu derivatives do not appear able to interact with formylpeptide receptors.