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Factory Hot Sell Dilthiazem Hydrochloride Powder, HCl Diltiazem CAS 33286-22-5
Cas No: 33286-22-5
USD $ 300.0-300.0 / Gram 1 Gram 500 Kilogram/Month Hebei Yingong New Material Technology Co.,Ltd . Contact Supplier
Diltiazem FACTORY Diltiazem hcl CAS 33286-22-5 available in stock
Cas No: 33286-22-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 2 Metric Ton/Month Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
Diltiazem / Diltiazem Hydrochloride / Diltiazem HCl with CAS 33286-22-5
Cas No: 33286-22-5
No Data 100 Gram 10 Metric Ton/Month Shanghai CRM New Material Technology Co., LTD Contact Supplier
Dilthiazem hydrochloride
Cas No: 33286-22-5
No Data 100 Gram 600 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier
Pharmaceutical Intermediate CAS 33286-22-5 Dilthiazem Hydrochloride / Diltiazem HCl / Diltiazem
Cas No: 33286-22-5
USD $ 100.0-150.0 / Kilogram 1 Kilogram 1000 Metric Ton/Day Wuhan Monad Medicine Tech Co.,LTD Contact Supplier
Dilthiazem hydrochloride Manufacturer/High quality/Best price/In stock
Cas No: 33286-22-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity 33286-22-5 Diltiazem HCl(USP31)
Cas No: 33286-22-5
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Diltiazem Hydrochloride Cas 33286-22-5 with best price
Cas No: 33286-22-5
No Data 1 Kilogram 20 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
High Quality 99% Diltiazem HCl 33286-22-5 GMP Manufacturer
Cas No: 33286-22-5
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
(+)-cis-DiltiazeM Hydrochloride
Cas No: 33286-22-5
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier

33286-22-5 Usage

Biological Activity

Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.

Uses

Diltiazem Hydrochloride is a calcium channel blocker with vasodilating activity. Anti-anginal; anti-hypertensive; anti-arrhythmic (class IV).

Manufacturing Process

β-Diethylaminoethyl chloride is condensed with 2-(4-methoxyphenyl)-3- hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one in a first step. Then a mixture of 1.5 grams of 2-(4-methoxyphenyl)-3-hydroxy-5-(βdimethylaminoethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one and 20 ml of acetic anhydride was heated on a water bath for 5 hours. The reaction mixture was evaporated under reduced pressure to remove acetic anhydride and the concentrated product was poured into ice water. The resulting mixture was made alkaline with sodium bicarbonate and extracted with chloroform. The chloroform layer was dried and evaporated to remove the solvent. The residue was dissolved in acetone, and an ethanol solution containing hydrogen chloride was added thereto producing 1.53 grams of 2-(4-methoxyphenyl)3- acetoxy-5-(β-dimethylaminoethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride having a melting point from 187° to 188°C.The starting material is made by reacting 4-methoxybenzaldehyde with ethyl chloroacetate; that product with sodium ethoxide; and that product with 2- aminothiophenol.

Originator

Herbesser,TANABE SEIYAKU,Japan,1974

Uses

Peripheral Vasodilator

Uses

A calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).

Chemical Properties

Fine Needles

General Description

Diltiazem hydrochloride,(+)-cis-3-(acetoxy)-5-[2(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)1,5-benzothiazepin-4(5H)one hydrochloride(Cardizem), was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.

Uses

An antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils

Brand name

Cardizem (Biovail); Cartia (Andrx); Dilacor (Watson); Diltzac (Apotex); Taztia (Andrx); Tiazac (Biovail).

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension.

Therapeutic Function

Coronary vasodilator

Uses

antihypertensive, sedative, antibacterial
InChI:InChI=1/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

33286-22-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (D3662)  (+)-cis-Diltiazem Hydrochloride  >98.0%(HPLC)(T) 33286-22-5 5g 890.00CNY Detail
TCI America (D3662)  (+)-cis-Diltiazem Hydrochloride  >98.0%(HPLC)(T) 33286-22-5 25g 2,690.00CNY Detail
Sigma-Aldrich (D1980000)  Diltiazem hydrochloride  European Pharmacopoeia (EP) Reference Standard 33286-22-5 D1980000 1,880.19CNY Detail
Sigma-Aldrich (Y0001141)  Diltiazem for system suitability  European Pharmacopoeia (EP) Reference Standard 33286-22-5 Y0001141 1,880.19CNY Detail
USP (1205003)  Diltiazem hydrochloride  United States Pharmacopeia (USP) Reference Standard 33286-22-5 1205003-200MG 4,662.45CNY Detail
Sigma (D2521)  (+)-cis-Diltiazem hydrochloride  ≥99% (HPLC) 33286-22-5 D2521-1G 919.62CNY Detail
Sigma (D2521)  (+)-cis-Diltiazem hydrochloride  ≥99% (HPLC) 33286-22-5 D2521-5G 3,691.35CNY Detail
Sigma (D2521)  (+)-cis-Diltiazem hydrochloride  ≥99% (HPLC) 33286-22-5 D2521-10G 6,124.95CNY Detail
Cerilliant (D-035)  Diltiazem hydrochloride solution  1.0 mg/mL in acetonitrile (as free base), ampule of 1 mL, certified reference material 33286-22-5 D-035-1ML 366.21CNY Detail

33286-22-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name diltiazem hydrochloride

1.2 Other means of identification

Product number -
Other names dilzem

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33286-22-5 SDS

33286-22-5Synthetic route

O-desacetyldiltiazem
42399-40-6

O-desacetyldiltiazem

acetic anhydride
108-24-7

acetic anhydride

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Stage #1: O-desacetyldiltiazem; acetic anhydride With dmap; triethylamine In dichloromethane for 3h; Heating / reflux;
Stage #2: With hydrogenchloride In methanol pH=2;
92%
With hydrogenchloride In ethanol; butanone at 90℃; for 1h;80%
With dmap In dichloromethane for 3h; Heating; Yield given;
(2S,3S)-5-(2-dimethylaminoethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride
75472-91-2

(2S,3S)-5-(2-dimethylaminoethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride

acetic anhydride
108-24-7

acetic anhydride

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Stage #1: (2S,3S)-5-(2-dimethylaminoethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride; acetic anhydride With dmap; triethylamine In dichloromethane
Stage #2: With hydrogenchloride In methanol pH=2;
92%
With pyridine; dmap
Isopropenyl acetate
108-22-5

Isopropenyl acetate

(2S,3S)-5-(2-dimethylaminoethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride
75472-91-2

(2S,3S)-5-(2-dimethylaminoethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
With methanesulfonic acid In chloroform for 0.75h; Heating;88.8%
(E)-1-(4-methoxyphenyl)-4,4-dimethylpent-1-en-3-one
2419-67-2, 24470-83-5, 41564-61-8

(E)-1-(4-methoxyphenyl)-4,4-dimethylpent-1-en-3-one

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 70 percent / urea hydrogen peroxide, DBU, immobilised poly-L-leucine / tetrahydrofuran / 28 h
2: 84 percent / MCPBA, KF / CH2Cl2 / 24 h
3: 90 percent / toluene / 17 h / Heating
4: 94 percent / xylene / 216 h / Heating
5: K2CO3 / ethyl acetate
6: pyridine, DMAP
View Scheme
(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
42399-49-5

(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / ethyl acetate
2: pyridine, DMAP
View Scheme
Multi-step reaction with 2 steps
1: 67 percent / NaH / dimethylformamide; paraffin; diethyl ether / 3 h / 70 °C
2: 80 percent / 2.) HCl / butan-2-one; ethanol / 1 h / 90 °C
View Scheme
Multi-step reaction with 2 steps
1: 88.2 percent / K2CO3 / H2O; ethyl acetate / 5 h / Heating
2: DMAP / CH2Cl2 / 3 h / Heating
View Scheme
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

(+-)-2-cyano-3-m-tolyl-propionic acid hydrazide

(+-)-2-cyano-3-m-tolyl-propionic acid hydrazide

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 87 percent / NaOMe / methanol / 40 h / Heating
2: 70 percent / urea hydrogen peroxide, DBU, immobilised poly-L-leucine / tetrahydrofuran / 28 h
3: 84 percent / MCPBA, KF / CH2Cl2 / 24 h
4: 90 percent / toluene / 17 h / Heating
5: 94 percent / xylene / 216 h / Heating
6: K2CO3 / ethyl acetate
7: pyridine, DMAP
View Scheme
tert-butyl (2R,3S)-3-(4-methoxyphenyl)glycidate
201804-22-0

tert-butyl (2R,3S)-3-(4-methoxyphenyl)glycidate

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / toluene / 17 h / Heating
2: 94 percent / xylene / 216 h / Heating
3: K2CO3 / ethyl acetate
4: pyridine, DMAP
View Scheme
(2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester
201804-23-1

(2S,3S)-3-(2-Amino-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / xylene / 216 h / Heating
2: K2CO3 / ethyl acetate
3: pyridine, DMAP
View Scheme
1-((2R,3S)-4-methoxyphenyloxiranyl)-2,2-dimethylpropan-1-one
201804-19-5

1-((2R,3S)-4-methoxyphenyloxiranyl)-2,2-dimethylpropan-1-one

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 84 percent / MCPBA, KF / CH2Cl2 / 24 h
2: 90 percent / toluene / 17 h / Heating
3: 94 percent / xylene / 216 h / Heating
4: K2CO3 / ethyl acetate
5: pyridine, DMAP
View Scheme
(2S,3S)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid
42399-48-4

(2S,3S)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / PTSA / xylene / 16 h / Heating
2: 88.2 percent / K2CO3 / H2O; ethyl acetate / 5 h / Heating
3: DMAP / CH2Cl2 / 3 h / Heating
View Scheme
(αS,βS,1R,2S)-β-<(2-aminophenyl)thio>-α-hydroxy-β-(4-methoxyphenyl)propanoic acid 2-phenylcyclohexyl ester hydrochloride
138382-02-2

(αS,βS,1R,2S)-β-<(2-aminophenyl)thio>-α-hydroxy-β-(4-methoxyphenyl)propanoic acid 2-phenylcyclohexyl ester hydrochloride

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 81 percent / 2 N NaOH / ethanol; H2O / 2 h / Heating
2: 88 percent / PTSA / xylene / 16 h / Heating
3: 88.2 percent / K2CO3 / H2O; ethyl acetate / 5 h / Heating
4: DMAP / CH2Cl2 / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 73.2 percent / PTSA / xylene / 16 h / Heating
2: 88.2 percent / K2CO3 / H2O; ethyl acetate / 5 h / Heating
3: DMAP / CH2Cl2 / 3 h / Heating
View Scheme
diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Conditions
ConditionsYield
With water; hydrogen bromide at 100℃; for 0.5h;96%
diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

cis(+)-3-hydroxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
23515-44-8

cis(+)-3-hydroxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Conditions
ConditionsYield
With lithium hydroxide; water In tetrahydrofuran at 160℃; for 0.0833333h; Microwave irradiation;94%
diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

O-desacetyldiltiazem
42399-40-6

O-desacetyldiltiazem

Conditions
ConditionsYield
In water Ambient temperature; Irradiation; decomposition of diltiazem in various solvents;
With sodium chloride at 79.85℃; Kinetics; Thermodynamic data; Activation energy; Further Variations:; Temperatures; relative humidity;
With hydrogenchloride at 39.85℃; pH=0.43; Kinetics; Further Variations:; pH-values; Reagents; Temperatures;
diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

diltiazem
42399-41-7

diltiazem

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate
With sodium carbonate In water pH=7.5;
With sodium hydrogencarbonate In water for 0.25h;
C62H68N16O24S4(4-)*4Na(1+)

C62H68N16O24S4(4-)*4Na(1+)

diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

C22H26N2O4S*ClH*C62H68N16O24S4(4-)*4Na(1+)

C22H26N2O4S*ClH*C62H68N16O24S4(4-)*4Na(1+)

Conditions
ConditionsYield
In aq. phosphate buffer pH=7.4; UV-irradiation;
diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

diltiazem acetylsalicylate hydrate

diltiazem acetylsalicylate hydrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / water / pH 7.5
2: diethyl ether / 20 °C
View Scheme
diltiazem hydrochloride
33286-22-5

diltiazem hydrochloride

diltiazem nicotinate

diltiazem nicotinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / water / pH 7.5
2: acetonitrile / 20 °C
View Scheme

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