75472-91-2 Usage
Uses
Used in Pharmaceutical Industry:
Desacetyl Diltiazem Hydrochloride is used as an active pharmaceutical ingredient for the treatment of various cardiovascular conditions, such as angina, hypertension, and arrhythmias. Its vasodilating properties help in improving blood flow and reducing the workload on the heart, thus providing relief from chest pain and lowering blood pressure.
Used in Research and Development:
Desacetyl Diltiazem Hydrochloride is also utilized in research and development for studying its potential therapeutic effects and mechanisms of action. This can lead to the discovery of new drug candidates and treatment strategies for cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 75472-91-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,4,7 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 75472-91:
(7*7)+(6*5)+(5*4)+(4*7)+(3*2)+(2*9)+(1*1)=152
152 % 10 = 2
So 75472-91-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2O3S.ClH/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14;/h4-11,18-19,23H,12-13H2,1-3H3;1H/t18-,19+;/m1./s1
75472-91-2Relevant academic research and scientific papers
Process for preparing diltiazem using a heterogeneous trifunctional catalyst
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Page 3, (2008/06/13)
The present invention comprises a simplified synthesis of (+)-diltiazem through IE-PdOsW wherein IE is ion-exchanger, catalyzed three-component coupling reaction and Fe3+-exchanged clay catalyzed ring opening of sulfite with 2-aminothiophenol followed by cyclization as key steps.
Improved procedure for Julia-Colonna asymmetric epoxidation of α,β-unsaturated ketones: Total synthesis of diltiazem and Taxol side-chain
Adger, Brian M.,Barkley, James V.,Bergeron, Sophie,Cappi, Michael W.,Flowerdew, Benjamin E.,Jackson, Mark P.,McCague, Ray,Nugent, Thomas C.,Roberts, Stanley M.
, p. 3501 - 3507 (2007/10/03)
Poly-L-leucine catalyses the asymmetric epoxidation of enones 1-6 efficiently in a non-aqueous medium to provide the epoxy ketones 7-12 (70-91% yield; 80 to ≥95% ee). The strategy was used to make diltiazem 16 and the Taxol side chain 23 in single enantiomer form.
