332903-74-9

Usage

Uses

Used in Pharmaceutical Industry:
(2-CHLORO-6-FLUOROPHENYL)-P-TOLYL-AMINE is used as a key intermediate in the synthesis of various pharmaceuticals for its capacity to bind with biological targets, contributing to the development of new drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, (2-CHLORO-6-FLUOROPHENYL)-P-TOLYL-AMINE is utilized as a component in the creation of pesticides and other crop protection agents, leveraging its chemical properties to control or eliminate pests and diseases affecting agricultural produce.
Used in Medicinal Chemistry Research:
(2-CHLORO-6-FLUOROPHENYL)-P-TOLYL-AMINE serves as a valuable compound in medicinal chemistry research, where it is employed to explore and understand its interactions with biological systems, potentially leading to the discovery of novel therapeutic agents.
Used in Drug Discovery:
This chemical is also used in drug discovery processes, where its unique structure and properties are assessed for potential applications in creating new medications that address unmet medical needs.

Upstream product

• 106-49-0 p-toluidine 
• 309721-44-6 2-bromo-3-fluoro-chlorobenzene 
• 76144-87-1 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl 
• 106-38-7 para-bromotoluene 
• 363-51-9 2-chloro-6-fluoroaniline 
• 16634-82-5 N-(p-tolyl)-2-chloroacetamide 
• 623-03-0 4-Cyanochlorobenzene 
• 817621-52-6 4-(2-chloro-6-fluoro-phenylamino)benzoic acid ethyl ester 

Downstream Products

• 332903-83-0 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one 
• 220991-20-8 lumiracoxib 
• 332903-78-3 2-chloro-N-(2-chloro-6-fluoro-phenyl)-N-p-tolylacetamide 

Relevant academic research and scientific papers

Intramolecular direct arylation in the synthesis of fluorinated carbazoles

The amination of 2-chloroanilines with aryl bromides and subsequent intramolecular direct arylation can be exploited in the synthesis of a range of fluorinated carbazoles, where the fluorine substituent can be introduced via the aniline, the aryl bromide or both substrates. Depending on substitution patterns, the two steps can either be performed in tandem in one-pot under microwave heating conditions or else require a two pot approach.

Process for phenylacetic acid derivatives

A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.

Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds

Various new N-aryl oxindoles were synthesized as intermediates for the preparation of pharmacologically active 2-(N-arylamino)-phenylacetic acids. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures, in addition to Buchwald-arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles. Graphical Abstract.

Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives

Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1is chloro or fluoro; R2is hydrogen or fluoro; R3is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4is hydrogen or fluoro; and R5is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.