33328-21-1

Basic information

• Product Name: phenyl-N'-(4-chlorophenyl)-N,N-dimethylcarbamimidothioate
• Synonyms: phenyl-N'-(4-chlorophenyl)-N,N-dimethylcarbamimidothioate
• CAS NO: 33328-21-1
• Molecular Weight: 290.817
• Mol File: 33328-21-1.mol

Chemical Properties

• CAS DataBase Reference: phenyl-N'-(4-chlorophenyl)-N,N-dimethylcarbamimidothioate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl-N'-(4-chlorophenyl)-N,N-dimethylcarbamimidothioate(33328-21-1)
• EPA Substance Registry System: phenyl-N'-(4-chlorophenyl)-N,N-dimethylcarbamimidothioate(33328-21-1)

Safety Data

• Hazardous Substances Data: 33328-21-1(Hazardous Substances Data)

Upstream product

• 2212-17-1 N,N-dimethyl-N'-p-chlorophenylthiourea 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 2771-67-7 N-dichloromethylene-4-chloroaniline 
• 55832-06-9 N-(4-Chlor-phenyl)-chlorthioformimidsaeurephenylester 
• 124-40-3 dimethyl amine 
• 7691-78-3 N,N-Dimethyl-N'-(4-chlor-phenyl)-chlorformamidin 
• 108-98-5 thiophenol 

Relevant articles and documents

Facile synthesis of S-arylisothioureas via the S-arylation of arylthioureas with aryl iodides in water

An environmentally benign, simple and highly efficient protocol for the synthesis of S-arylisothiourea derivatives has been achieved in good to excellent yields by reacting a series of aryl iodides with arylthioureas, using inexpensive CuSO4·5H2O as catalyst in water without PTC (phase transfer catalyst). The protocol features easy performance, good to excellent yields, good tolerance towards a variety of functional groups, which could be useful for the preparation of some biologically active compounds.

An Efficient Chan–Lam S-Arylation of Arylthioureas with Arylboronic Acids

A convenient and efficient protocol has been developed for the preparation of aryl-isothioureas based on the Chan–Lam C–S coupling reaction. The desired aryl-isothioureas were synthesized in good yields (up to 95 %) in the presence of Cu(OAc)2·H2O as catalyst and bipyridine as ligand. A variety of functional groups on the aryl-thiourea and arylboronic acid reagents are tolerated. The method features mild reaction conditions and good yields, thereby illustrating its practical synthetic value in organic synthesis.