2212-17-1

Basic information

• Product Name: 3-(4-chlorophenyl)-1,1-dimethylthiourea
• Synonyms: 1,1-Dimethyl-3-(p-chlorophenyl)thiourea; methanethiol, 1-[(4-chlorophenyl)imino]-1-(dimethylamino)-, (Z)-; N'-(4-Chlorophenyl)-N,N-dimethylcarbamimidothioic acid
• CAS NO: 2212-17-1
• Molecular Formula: C₉H₁₁ClN₂S
• Molecular Weight: 214.715
• Mol File: 2212-17-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 283.3°C at 760 mmHg
• Flash Point: 125.1°C
• Density: 1.292g/cm³
• Vapor Pressure: 0.00319mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 3-(4-chlorophenyl)-1,1-dimethylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-1,1-dimethylthiourea(2212-17-1)
• EPA Substance Registry System: 3-(4-chlorophenyl)-1,1-dimethylthiourea(2212-17-1)

Safety Data

• Hazardous Substances Data: 2212-17-1(Hazardous Substances Data)

Upstream product

• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 124-40-3 dimethyl amine 
• 137-26-8 Thiram 
• 106-47-8 4-chloro-aniline 
• 6906-32-7 N,N,2-Trimethyl-1-propen-1-amin 

Downstream Products

• 33328-21-1 phenyl-N'-(4-chlorophenyl)-N,N-dimethylcarbamimidothioate 
• 1329429-80-2 3-(4-chlorophenyl)-1,1-dimethyl-2-phenyl-isothiourea 
• 1329429-78-8 N'-(4-chlorophenyl)-N,N-dimethyl-2-phenylsulfanyl-benzamidine 
• 7464-20-2 6-chloro-N,N-dimethylbenzo[d]thiazol-2-amine 

Relevant articles and documents

Method for preparing aryl isothiourea

The invention discloses a method for preparing aryl isothiourea, wherein hydride is suspended in a solvent, and thiourea is sequentially added. O diiodo benzene followed by reaction to prepare aryl isothiosemicarbazone. The isothiourea structure is widely

Synthesis and pesticidal properties of thio and seleno analogs of some common urea herbicides

Thio and seleno analogs of fenuron, isoproturon, chlorotoluron, metoxuron, monuron, and diuron were synthesized from the corresponding aryl amines. Their reaction with thiophosgene leads to isothiocyanates. Aryl amines were also converted (via isocyanides) to isoselenocyanates. The reaction of both isothio- and isoselenocyanates with dimethylamine affords the corresponding thio and seleno analogs of the above-mentioned urea herbicides. Herbicidal activity of the synthesized compounds was slightly lower than the activity of the parent urea herbicides. The thio and seleno analogs as well as the parent ureas showed good fungicidal activity at a concentration of 200 ppm against selected fungi.

Reaction of 1,4,2-Dithiazolium Salts with Amino Compounds

Systematic studies on the behavior of 1,4,2-dithiazolium cations (1) toward various amino compounds (ammonia, aliphatic and aromatic amines, hydrazine, semicarbazide, thiosemicarbazide derivatives, etc.) were performed.The reaction pathway could be classified into three types depending on possibile three fission modes of the initially-formed adduct.The main products were 5-imino-1,4,2-dithiazole, thiourea, and 1,3,4-thiadiazole derivatives, through the three different pathways, respectively.In order to clarify the factors controlling the reaction courses, the reactions of 1 with p-substituted aniline derivatives were carried out under systematically varying conditions.The strength of bases and the polaritiy of solvents had clear influence on the reactivity.The reaction mechanism is also discussed.