2212-17-1

Upstream product

• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 124-40-3 dimethyl amine 
• 137-26-8 Thiram 
• 106-47-8 4-chloro-aniline 
• 6906-32-7 N,N,2-Trimethyl-1-propen-1-amin 

Downstream Products

• 7464-20-2 6-chloro-N,N-dimethylbenzo[d]thiazol-2-amine 
• 1329429-80-2 3-(4-chlorophenyl)-1,1-dimethyl-2-phenyl-isothiourea 
• 1329429-78-8 N'-(4-chlorophenyl)-N,N-dimethyl-2-phenylsulfanyl-benzamidine 
• 33328-21-1 phenyl-N'-(4-chlorophenyl)-N,N-dimethylcarbamimidothioate 

Relevant academic research and scientific papers

Method for preparing aryl isothiourea

The invention discloses a method for preparing aryl isothiourea, wherein hydride is suspended in a solvent, and thiourea is sequentially added. O diiodo benzene followed by reaction to prepare aryl isothiosemicarbazone. The isothiourea structure is widely

Insertion of arynes into thioureas: A new amidine synthesis

Arynes, generated from trimethylsilyl phenyltriflate precursors, have been found to react with thioureas via a formal π-insertion into the C=S bond. The reaction contrasts with that of ureas, which proceeds via benzyne σ-insertion into the C-N bond, and r

Synthesis and pesticidal properties of thio and seleno analogs of some common urea herbicides

Thio and seleno analogs of fenuron, isoproturon, chlorotoluron, metoxuron, monuron, and diuron were synthesized from the corresponding aryl amines. Their reaction with thiophosgene leads to isothiocyanates. Aryl amines were also converted (via isocyanides) to isoselenocyanates. The reaction of both isothio- and isoselenocyanates with dimethylamine affords the corresponding thio and seleno analogs of the above-mentioned urea herbicides. Herbicidal activity of the synthesized compounds was slightly lower than the activity of the parent urea herbicides. The thio and seleno analogs as well as the parent ureas showed good fungicidal activity at a concentration of 200 ppm against selected fungi.

Reaction of 1,4,2-Dithiazolium Salts with Amino Compounds

Systematic studies on the behavior of 1,4,2-dithiazolium cations (1) toward various amino compounds (ammonia, aliphatic and aromatic amines, hydrazine, semicarbazide, thiosemicarbazide derivatives, etc.) were performed.The reaction pathway could be classified into three types depending on possibile three fission modes of the initially-formed adduct.The main products were 5-imino-1,4,2-dithiazole, thiourea, and 1,3,4-thiadiazole derivatives, through the three different pathways, respectively.In order to clarify the factors controlling the reaction courses, the reactions of 1 with p-substituted aniline derivatives were carried out under systematically varying conditions.The strength of bases and the polaritiy of solvents had clear influence on the reactivity.The reaction mechanism is also discussed.

Cycloaddition Reactions of Heterocumulenes, XXVI. Cycloadducts from Aryl Isothiocyanates and 2,2-Disubstituted Enamines

Aryl isothiocyanates 1 react with enamines 2 to give two types of 2:1 cycloadducts.Below 50 deg C, 1a - g and 2 give rise to 6-imino-1,3-thiazine-2-thiones 5, the constitutions of which are proved by an X-ray analysis of 5c.Above 50 deg C or starting from 4-nitrophenyl isothiocyanate (1h), 2,4-dithiouracils 6 are formed. 1:1 cycloadducts of the reactants are detected spectroscopically; on workup, they hydrolyze to give 2-formylthiopropionanilides 9.