876156-35-3

Basic information

• Product Name: 5-vinylisobenzofuran-1(3H)-one
• Synonyms: 5-vinylisobenzofuran-1(3H)-one;5-ethenyl-2-benzofuran-1(3H)-one
• CAS NO: 876156-35-3
• Molecular Formula: C10H8O2
• Molecular Weight: 160.16932
• Mol File: 876156-35-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-vinylisobenzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-vinylisobenzofuran-1(3H)-one(876156-35-3)
• EPA Substance Registry System: 5-vinylisobenzofuran-1(3H)-one(876156-35-3)

Safety Data

• Hazardous Substances Data: 876156-35-3(Hazardous Substances Data)

Upstream product

• 1255209-27-8 C₁₁H₁₂O₅S 
• 64169-34-2 5-bromophthalide 
• 65399-05-5 5-amino-3H-isobenzofuran-1-one 
• 3676-85-5 4-aminophthalimide 
• 89-40-7 4-nitrophthalimide 
• 108-05-4 vinyl acetate 

Downstream Products

• 333333-34-9 1-oxo-1,3-dihydroisobenzofuran-5-carbaldehyde 

Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent

A nickel-catalyzed reductive cross-coupling has been achieved using (hetero)aryl bromides and vinyl acetate as the coupling partners. This mild, applicable method provides a reliable access to a variety of vinyl arenes, heteroarenes, and benzoheterocycles, which should expand the chemical space of precursors to fine chemicals and polymers. Importantly, a sustainable solvent, dimethyl isosorbide, is used, making this protocol more attractive from the point of view of green chemistry.

Preparation method of novel isobenzofuranone intermediate

The invention discloses a synthetic method of an important intermediate of novel diuretic drug ROMK inhibitor. The synthetic method comprises the following steps: adopting 4-nitro phthalimide as the starting material, performing two-step reaction, diazotization reaction, Suzuki reaction and epoxidation reaction, thus obtaining the important intermediate 5-epoxy ethyl isobenzofuranone of the ROMK inhibitor. The preparation method provided by the invention is mild in route reaction conditions, simple in after-treatment, high in yield, and capable of avoiding the use of toxic gases and bioenzymecatalysts.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.