333349-91-0

Upstream product

• 615-43-0 2-iodophenylamine 
• 586-38-9 3-Methoxybenzoic acid 
• 1711-05-3 m-anisoyl chloride 

Downstream Products

• 865348-63-6 N-(2-iodophenyl)-3-methoxy-N-methylbenzamide 
• 38088-95-8 8-methoxyphenanthridine-6(5H)-one 
• 1103883-07-3 C₁₉H₂₀INO₄ 
• 32959-59-4 2-(3-methoxyphenyl)benzoxazole 
• 10002-44-5 2-(3'-methoxyphenyl)benzothiazole 
• 56071-04-6 2-(3-methoxyphenyl)quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Dibrominative Spirocyclization of 2-Butynolyl Anilides: Synthesis of gem-Dibromospirocyclic Benzo[ d][1,3]oxazines and Their Application in the Synthesis of 4 H-Furo[3,2- b]indoles

The combination of catalytic aqueous hydrochloric acid (HCl) and N-bromosuccinimide (NBS) generated electrophilic bromine monochloride (BrCl), which readily induced spiroannulation of 2-alkynolyl anilides (n = 1-3) to form gem-dibromospirocyclic benzo[d][

Lewis Acid Catalyzed Atom-Economic Synthesis of C2-Substituted Indoles from o-Amido Alkynols

Herein we have disclosed a Zn(OTf)2 catalyzed synthesis of C2-alkyl substituted indole derivatives via unprecedented carbonyl group migration from o-amido alkynols. The key features of this protocol involve N,O-carbonyl group migration, broad s

Cu-catalyzed in situ generation of thiol using xanthate as a thiol surrogate for the one-pot synthesis of benzothiazoles and benzothiophenes

A new copper-catalyzed in situ generation of aryl thiolates strategy was successfully developed for the one-pot synthesis of substituted benzothiazoles from 2-iodoanilides using xanthate as a thiol precursor. A wide range of 2-iodoanilides with both electron-releasing and electron-withdrawing groups produced the corresponding benzothiazoles in good yields. Further, this one-pot protocol was successfully utilized for the synthesis of a potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzo[d]thiazole (PMX 610). Finally, the copper-catalyzed in situ generation of aryl thiolates strategy was successfully applied for the domino synthesis of substituted benzothiophenes from o-haloalkynyl benzenes using xanthate as a thiol precursor.

Biaryl coupling reactions of 3-methoxy-n-(2-iodophenyl)-N-methylbenzamide and 3-methoxycarbonyl-N-(2-iodophenyl)-N-methylbenzamide using palladium reagent

We examined palladium-assisted biaryl coupling reactions of 3-methoxy and 3-methoxycarbonyl benzanilides, and propose an aspect of the mechanism involved in forming a biaryl bond using Pd reagent.