10002-44-5Relevant academic research and scientific papers
Rapid and convenient thermal or microwave-assisted synthesis of substituted 2-phenylbenzothiazoles
Weekes, Ashley A.,Dix, Matthew C.,Bagley, Mark C.,Westwell, Andrew D.
, p. 3027 - 3032 (2010)
A simple one-step method for the synthesis of biologically relevant 2-phenylbenzothiazoles has been developed, using sodium metabisulfite as an oxidant following condensation between 2-aminothiophenol and substituted benzaldehydes. Attractive features of
Alumina as a support and catalyst for the synthesis of benzothiazoles in solvent-free condition
Ding, Mei-Fang,Chen, Chia-Pei,Lin, Shaw-Tao
, p. 645 - 649 (2013)
Arylbenzothiazole (4) and benzothiazolylcoumarins (5) were prepared by the condensation of 2-aminothiophenol (1) and hydroxybenzaldehydes (2) and 3-ethoxycarbonylcoumarinnin (3), respectively, in solvent- free condition. Of the solid support used,γ-Al2O3 demonstrated the best activity. Alinear regression line obtained from correlation between relative formation rate and Hammett constants with slope of 0.653 suggested that this condensation process is less sensitive to the substituents on the phenyl ring due to low efficacy of polarization in the solid state. In general, good yields (>80% yield) were obtained for the formation of 4. Conversely, yields of 5 were poor, because of γ-Al2O3 catalytic decomposition of 3 to form 2 (without P2O5) and coumarin (with P2O5).
Antidiabetic potential and enzyme kinetics of benzothiazole derivatives and their non-bonded interactions with α-glucosidase and α-amylase
Puranik, Ninad V.,Puntambekar, Hemalata M.,Srivastava, Pratibha
, p. 805 - 816 (2016)
Benzothiazole derivatives were synthesized and their antidiabetic potential evaluated using α-glucosidase, α-amylase, non-enzymatic glycosylation of hemoglobin and advanced glycation end product inhibition assays. Compound 3l showed low IC50 va
An efficient and green synthesis of 2-arylbenzothiazoles in an ionic liquid, [pmIm]Br under microwave irradiation
Ranu, Brindaban C.,Jana, Ranjan,Dey, Suvendu S.
, p. 274 - 275 (2004)
An efficient and green procedure for the synthesis of 2-arylbenzothiazoles has been developed by a simple condensation of 2-aminothiophenol and aromatic aldehyde in an inexpensive ionic liquid, 1-pentyl-3-methylimidazolium bromide ([pmIm]-Br) by microwave irradiation under solvent and catalyst-free condition. The ionic liquid is recycled for subsequent reactions.
An efficient copper(II)-catalyzed synthesis of benzothiazoles through intramolecular coupling-cyclization of N-(2-chlorophenyl)benzothioamides
Jaseer,Prasad,Dandapat, Arpan,Sekar, Govindasamy
, p. 5009 - 5012 (2010)
A wide range of 2-aryl or 2-alkyl-substituted benzothiazoles are synthesized through intramolecular C(aryl)-S bond forming-cyclization using copper(II)-BINAM-catalyzed coupling of less reactive N-(2-chlorophenyl) benzo or alkylthioamide under mild reaction conditions (82 °C).
Elemental sulfur mediated cyclization via redox strategy: Synthesis of benzothiazoles from o-chloronitrobenzenes and benzyl chlorides
Wang, Xin,Miao, Dazhuang,Li, Xiaotong,Hu, Renhe,Yang, Zhao,Gu, Ren,Han, Shiqing
, p. 5194 - 5199 (2017)
A novel metal-free synthesis of 2-substituted benzothiazoles from easily available o-chloronitrobenzenes and benzyl chlorides using elemental sulfur as traceless oxidizing agent has been developed. The protocol provides a simple, efficient, and atom-economic way to access to benzothiazoles in moderate to excellent yields. And the approach exhibited good functional group tolerance.
Synthesis and electronic absorption and fluorescence of 2-arylbenzothiazole derivatives
Chen, Lianqing,Yang, Chuluo,Li, Suyue,Qin, Jingui
, p. 317 - 322 (2007)
A series of new 2-arylbenzothiazoles have been prepared in high yields by Jacobson's cyclization condensation of 2-aminobenzenethiol with benzoyl chloride or benzaldehyde derivatives under three different routes. These compounds have been fully characterized by EA, IR, NMR and MS. The electronic absorption and fluorescence of these compounds have been systematically investigated for the first time. The relationships between their photophysical properties and structures have been discussed. The alteration of absorption and emission wavelengths can be elucidated by Hammett's substituent constants.
Metal-free aerobic oxidative C-N bond cleavage of tertiary amines for the synthesis of N-heterocycles with high atom efficiency
Chen, Xiuling,Chen, Tieqiao,Zhou, Yongbo,Han, Daoqing,Han, Li-Biao,Yin, Shuang-Feng
, p. 3802 - 3807 (2014)
An efficient metal-free aerobic oxidative C-N bond cleavage of tertiary amines has been developed to construct N-heterocycles using molecular oxygen as the sole oxidant with high atom efficiency, in which all of the three alkyl groups in tertiary amines can be utilized and transformed into N-heterocycles. This journal is the Partner Organisations 2014.
Copper containing nanosilica thioalated dendritic material: A recyclable catalyst for synthesis of benzimidazoles and benzothiazoles
Zakeri, Maryam,Moghadam, Majid,Mirkhani, Valiollah,Tangestaninejad, Shahram,Mohammadpoor-Baltork, Iraj,Pahlevanneshan, Zari
, (2018)
In this paper, the design and characterization of a new heterogeneous catalyst by incorporation of copper ions into the nanosilica modified by thiole–based dendrimer are reported. The prepared catalyst was characterized by FT–IR, TGA, elemental analysis,
Iron catalyzed efficient synthesis of 2-arylbenzothiazoles from benzothiazole and olefins using environmentally benign molecular oxygen as oxidant
Khemnar, Ashok B.,Bhanage, Bhalchandra M.
, p. 8939 - 8942 (2014)
A novel protocol for iron catalyzed arylation of benzothiazole with olefins has been developed using molecular oxygen as a greener oxidant. The reaction worked smoothly using inexpensive and easily available iron as a catalyst for the synthesis of 2-arylbenzothiazole derivatives in good to excellent yields.
