333363-79-4

Basic information

• Product Name: 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE
• Synonyms: 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE;1-phenyl-5-(trifluoroMethyl)-1H-pyrazole;1-Phenyl-5-(trifluoromethyl)pyrazole
• CAS NO: 333363-79-4
• Molecular Formula: C₁₀H₇F₃N₂
• Molecular Weight: 212.1711896
• Mol File: 333363-79-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE(333363-79-4)
• EPA Substance Registry System: 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE(333363-79-4)

Safety Data

• Hazardous Substances Data: 333363-79-4(Hazardous Substances Data)

Usage

General Description

5-(Trifluoromethyl)-1-phenyl-1H-pyrazole is a chemical compound with the molecular formula C9H6F3N3. It is a pyrazole derivative with a trifluoromethyl group attached to the fifth position of the pyrazole ring and a phenyl group attached to the first position. 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE is commonly used in organic synthesis and pharmaceutical research due to its unique structure and potential biological activities. It has been studied for its potential as an anti-inflammatory and anti-cancer agent, as well as its ability to modulate certain biological pathways. Additionally, its trifluoromethyl group makes it a useful building block for the synthesis of other fluorinated compounds, which are of interest in various fields including medicinal and materials chemistry.

Upstream product

• 59938-06-6 (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 
• 100-63-0 phenylhydrazine 
• 59938-06-6 4-ethoxy-1,1,1-trifluoro-3-butene-2-one 
• 103-03-7 1-phenylsemicarbazide 

Downstream Products

• 497833-01-9 4-bromo-1-phenyl-5-trifluoromethyl-1H-pyrazole 
• 497833-12-2 4-bromo-1-phenyl-5-trifluoromethyl-3-pyrazolecarboxylic acid 
• 98534-81-7 1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Synthesis of fluorinated pyrazole derivatives from β-alkoxyvinyl trifluoroketones

1,1,1-Trifluoro-4-ethoxy-3-butene-2-one, 3-trifluoroacetyl-3, 4-dihydro-2H-pyran or furan reacted readily with pentafluorophenylhydrazine or per(poly)fluoroacectylhydrazine RfCO-NHNH2 (Rf: BrCF2, C3F7) to give N-substituted-5-hydroxy-5-trifluoromethyl heterocycles Y-N-N=CH-CH(R)C(OH)CF3 (Y: H, Arf or RfCO), which were dehydrated by treatment with P2O5 or SOCl2 to form N-substituted 5-trifluoromethyl pyrazoles Y-N-N=CH-C(R)=CCF3 (Y: H, Arf or RfCO) in good yields.

New strategy for the regioselective synthesis of 1-phenyl-3- trifluoromethyl-1H-pyrazoles

A regioselective synthesis of 3-trifluoromethyl-1-phenyl-1H-pyrazoles (1,3-isomers) as well as their 1,5-isomers (5-trifluoromethyl-1-phenyl-1H- pyrazoles), is described. The 1,3-isomers were obtained from the reaction of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones with arylhydrazones followed by deprotective hydrolysis while the 1,5-isomer was obtained by direct cyclocondensation of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones with phenylhydrazine. An unequivocal assignment of the 1,3- and 1,5-isomers of the pyrazole products is given.

Synergic effects of ionic liquid and microwave irradiation in promoting trifluoromethylpyrazole synthesis

The synthesis of 5-trifluoromethyl-1-phenyl-1H-pyrazoles from the reactions of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones [CF3C(O)CH=C(R 1)OR, where R = Me, Et; R1= H, Me, Bu, i-Bu, Ph, 4-MeC6H4, 4-FCsu