103-03-7

Basic information

• Product Name: 1-PHENYLSEMICARBAZIDE
• Synonyms: 1-Phenylsemicarbazide,99%;1-PhenylseMicarbazide, 99% 25GR;1-Phenylsemicarbazide 99%;1-Phenylsemicarbazide hydrochloride;1-carbamoyl-2-phenyl-hydrazin;1-Carbamoyl-2-phenylhydrazine;1-Phenylhydrazinecarboxamide;2-phenyldiazenecarboxamide
• CAS NO: 103-03-7
• Molecular Formula: C₇H₉N₃O
• Molecular Weight: 151.17
• EINECS: 203-072-3
• Product Categories: Carbonyl Compounds;Organic Building Blocks;Ureas
• Mol File: 103-03-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 171-174 °C(lit.)
• Boiling Point: 273.17°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.2100 (rough estimate)
• Refractive Index: 1.5860 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: acetone: very soluble(lit.)
• PKA: 11.16±0.43(Predicted)
• BRN: 743311
• CAS DataBase Reference: 1-PHENYLSEMICARBAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYLSEMICARBAZIDE(103-03-7)
• EPA Substance Registry System: 1-PHENYLSEMICARBAZIDE(103-03-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 45-36/37/39-26
• WGK Germany: 3
• RTECS: FD0575000
• TSCA: Yes
• Hazardous Substances Data: 103-03-7(Hazardous Substances Data)

Usage

Uses

1-Phenylsemicarbazide was used in the synthesis of a series of alkyl(aryl/heteroaryl) substituted 3-trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs by the cyclocondensation reactions with 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones.

Brand name

Antipyretic dellepsoids d26.

World Health Organization (WHO)

Phenicarbazide, which has analgesic and antipyretic activity, was introduced in the 1970s. It has been withdrawn in at least one country on grounds of its adverse effect profile and it appears to have fallen into disuse in others.

Purification Methods

Crystallise it from water and dry it in a vacuum over KOH. [Beilstein 15 H 287, 15 II 106, 15 III 184, 15 IV 180.]

InChI:InChI=1/C7H7N3O/c8-7(11)10-9-6-4-2-1-3-5-6/h1-5H,(H2,8,11)

Upstream product

• 934-48-5 3,5-dimethylpyrazole-1-carboxamide 
• 100-63-0 phenylhydrazine 
• 590-28-3 potassium cyanate 
• 64-19-7 acetic acid 
• 57-13-6 urea 
• 5338-16-9 dicyanodiamidine sulfate 
• 51-79-6 urethane 
• 7732-18-5 water 
• 7647-01-0 hydrogenchloride 
• 506-68-3 bromocyane 
• 64-17-5 ethanol 
• 506-77-4 cyanogen chloride 
• 71-43-2 benzene 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 76033-80-2 1-benzoyl-1-phenyl semicarbazide 
• 53723-90-3 1-acetyl-1-phenyl semicarbazide 
• 109047-22-5 1-chloroacetyl-1-phenyl semicarbazide 
• 140-22-7 1,5-diphenylcarbazide 
• 6942-46-7 1-phenylurazole 
• 87-87-6 2,3,5,6-tetrachlorobenzene-1,4-diol 
• 4203-28-5 phenyl-diazenecarboxylic acid amide 
• 4231-68-9 3-hydroxy-1-phenyl-1,2,4-1H-triazole 
• 59-88-1 phenylhydrazine hydrochloride 
• 7664-41-7 ammonia 
• 15719-64-9 methylammonium carbonate 
• 100-63-0 phenylhydrazine 
• 622-37-7 Phenyl azide 
• 1227476-15-4 Azobenzene 

Relevant articles and documents

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Synthesis of novel halobenzyloxy and alkoxy 1,2,4-triazoles and evaluation for their antifungal and antibacterial activities

A new class of halobenzyloxy or alkoxy 1,2,4-triazoles and their hydrochlorides were synthesized through cyclization starting from commercially available phenylhydrazine. The structures were characterized by MS, IR and 1H NMR spectra as well as elemental analyses. All the synthesized compounds were screened for their antibacterial activities in vitro against Staphylococcus aureus (ATCC29213), methicillin-resistant Staphylococcus aureus (N315), Bacillus subtilis, Escherichia coli (ATCC25922), Pseudomonas aeruginosa, Shigella dysenteriae, Eberthella typhosa, and antifungal activities against Candida albicans (ATCC76615), Aspergillus fumigatus by broth microdilution assay method. The results of preliminary bioassay indicated that 3-(2,4- difluorobenzyloxy)-1-phenyl-1H-1,2,4-triazole hydrochloride exhibited the best inhibitory activity with an MIC value of 56.25 μM against P. aeruginosa superior to Chloramphenicol, and showed comparable activity with Chloramphenicol against E. coli (ATCC25922).

Gene delivery compounds

Compounds having the structure: wherein R1, R2 and R3 are each independently a C0-12 substituent selected from the group consisting of: hydrogen, a heteroatom, alkyl, alkenyl, alkynyl, heteroatom substituted alkyl, heteroatom substituted alkenyl, heteroatom substituted alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl; where the heteroatom is selected from the group consisting of: N, O and S; and where (A) is a single or double bond between N and R3. Further the C0-12 substituent is linear, branched or cyclic and optionally includes a pendant moiety selected from the group consisting of: carbonyl, hydroxyl, carboxyl, amine, thiol, thioester, thioether, phosphate, alkoxy, aryl, arylalkyl, sulfonamide and alkyl halide. Further, compounds 6883, 6898, 6975, 7036, 7064 and 8496 are provided. A process is provided for activating gene transfer in a subject by administering a pharmaceutically effective amount of a gene transfer activating compound to a subject and delivering pharmaceutically effective amount of a vector containing a nucleic so that the nucleic acid is transcribed in a target cell of the subject. A process for activating gene transfer to a cell is provided. A kit for activating gene transfer is provided.