333399-44-3

Upstream product

• 53449-14-2 7-chloro-6-nitro-4(3H)-quinazolinone 
• 162012-71-7 4,7-dichloro-6-nitro-quinazoline 
• 5900-59-4 2-amino-4-chlorobenzamide 
• 31374-18-2 7-chloro-3,4-dihydroquinazolin-4-one 
• 110-85-0 piperazine 
• 333400-90-1 7-chloro-4-[2-(4-chlorophenyl)ethylamino]-6-nitroquinazoline 

Downstream Products

• 333399-49-8 4-[2-(4-chlorophenyl)ethylamino]-7-(4-formylpiperazin-1-yl)-6-nitroquinazoline 

Relevant academic research and scientific papers

NOVEL QUINAZOLINE DERIVATIVES

Quinazoline derivatives represented by the general formula (1) or a pharmaceutically acceptable salt thereof in said formula R1is nitro or halogen; R2and R4are each hydrogen, C1-4alkyl, carboxyl, or C2-5alkoxycarbonyl; R3is hydrogen, amino, optionally substituted C1-4alkyl, C1-4alkanoyl, or C2-5alkoxycarbonyl; W is carbon or nitrogen; and m is 0 to 2.

Structure-activity relationships of quinazoline derivatives: Dual-acting compounds with inhibitory activities toward both TNF-α production and T cell proliferation

We synthesized 4-chlorophenethylaminoquinazoline derivatives and evaluated their inhibitory activities toward both TNF-α production and T cell proliferation responses. Compound 2f, containing a piperazine ring at the C(7)-position of the quinazoline ring, exhibited more potent inhibitory activities toward both than the lead compound 1a. A smaller N-substituent in the piperazine ring was required for inhibition of TNF-α production.