333422-01-8

Basic information

• Product Name: C₁₀H₁₈O₄
• CAS NO: 333422-01-8
• Molecular Weight: 202.251
• Mol File: 333422-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₈O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₈O₄(333422-01-8)
• EPA Substance Registry System: C₁₀H₁₈O₄(333422-01-8)

Safety Data

• Hazardous Substances Data: 333422-01-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 22483-21-2 isobutylidenebenzylamine 
• 64482-41-3 (3E)-4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)]but-3-en-2-one 
• 78-84-2 isobutyraldehyde 
• 100-46-9 benzylamine 

Relevant articles and documents

4-Piperidones from enantiomerically pure enones. Synthesis of 6-alkylsubstituted 4-oxo-pipecolic acid derivatives

The cyclization of the enantiomerically pure α,β-unsaturated ketone 1, an aliphatic aldehyde 3 and ammonia or benzylamine gives diastereoselectively cis-piperidones 4/4′. Although only modest yields were obtained, the presented cyclization has the advantage of being a single step reaction. The products 4 can serve as precursors forall-cis-4-hydroxypiperidones 5 and novel pipecolic acid derivatives 9.