33351-38-1Relevant academic research and scientific papers
Solid-phase synthesis of 5,6-dihydropyrimidine-2,4-diones
Kolodziej, Stephen A.,Hamper, Bruce C.
, p. 5277 - 5280 (1996)
A series of 1,3-disubstituted-5,6-dihydropyrimidine-2,4-diones 1 are prepared by solid phase organic chemistry using a cyclization-cleavage strategy from readily available amines and isocyanates. A acrylate ester of Wangs resin is treated with primary amines to afford N-substituted β-aminoesters followed by treatment with isocyanates to afford β-ureido ester 4. Cyclization-cleavage of the bound ureido ester under acidic conditions gave direct formation of 5,6-dihydropyrimidinedione 1.
