3336-65-0

Usage

Uses

Used in Chemical Synthesis:
2-[AMINO(PHENYL)METHYLENE]MALONONITRILE is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure allows it to be a valuable building block in the creation of complex molecules, which can be further utilized in different applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-[AMINO(PHENYL)METHYLENE]MALONONITRILE is used as a research compound for the development of new drugs. Its structure may provide insights into the design of novel therapeutic agents, particularly in the area of medicinal chemistry.
Used in Material Science:
2-[AMINO(PHENYL)METHYLENE]MALONONITRILE is used as a component in the development of new materials, such as polymers and composites. Its properties may contribute to the creation of materials with unique characteristics, which can be applied in various industries, including electronics and aerospace.
Used in Analytical Chemistry:
In analytical chemistry, 2-[AMINO(PHENYL)METHYLENE]MALONONITRILE is used as a reference compound for the calibration of analytical instruments and the development of new analytical methods. Its distinct structure and properties make it a useful tool for researchers in this field.

InChI:InChI=1/C10H7N3/c11-6-9(7-12)10(13)8-4-2-1-3-5-8/h1-5,9,13H/b13-10-

Upstream product

• 4364-80-1 2-phenyl-1,1,2-tricyanoethylene 
• 100-47-0 benzonitrile 
• 109-77-3 malononitrile 
• 46177-21-3 2-benzoylmalononitrile 
• 1629803-26-4 (E)-2-chloro-2-[(chloroimino)(phenyl)methyl]malononitrile 
• 98-88-4 benzoyl chloride 
• 5515-36-6 α-cyano-β-hydroxycinnamonitrile 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 42754-56-3 2-(methoxyphenylmethylene)malononitrile 

Downstream Products

• 67247-90-9 2,4-dichloro-2,6-diphenyl-2λ⁵-[1,3,2]diazaphosphinine-5-carbonitrile 
• 28862-14-8 2,2,4-trichloro-6-phenyl-2λ⁵-[1,3,2]diazaphosphinine-5-carbonitrile 
• 72553-03-8 4-chloro-2,2,6-triphenyl-2λ⁵-[1,3,2]diazaphosphinine-5-carbonitrile 
• 142386-61-6 Kalium-N-(2-methyl-6-phenyl-5-cyanpyrimidin-4-yl)cyanamid 
• 142232-05-1 4-Benzamido-2-methylthio-6-phenylpyrimidin-5-carbonitril 
• 142232-04-0 2,6-Diphenyl-4-ureidopyrimidin-5-carbonitril 
• 76990-22-2 2-<(N,N-dimethylaminomethylene)amino>-1,1-dicyano-2-phenylethene 
• 92119-50-1 3-amino-2-cyano-3-phenylthioacrylamide 
• 136498-25-4 5-imino-7-phenyl-2,3-dihydro-5H-thiazolo<3,2-a>pyrimidine-6-carbonitrile 
• 88009-93-2 5-amino-3-phenyl-isothiazole-4-carbonitrile 
• 158042-65-0 5-amino-3-phenylisothiazole-4-carboxamide 
• 158042-61-6 3-phenylisothiazolo<5,4-d>pyrimidin-4(5H)-one 
• 76990-10-8 4-n-propylamino-5-cyano-6-phenylpyrimidine 
• 76990-09-5 4-allylamino-5-cyano-6-phenylpyrimidine 

Relevant academic research and scientific papers

PhICl2-mediated conversion of enamines into α, N -dichloroimines and their reverse conversion mediated by zinc in methanol

Treatment of enamine compounds with iodobenzene dichloride (PhICl 2) conveniently gives a variety of α,N-dichloroimines in high yields. This approach allows the double insertion of the chloro moiety, which is postulated to take place via the io

Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation

The synthesis and structure-activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic profile of 10 and 21 with adequate CNS penetration, required for in vivo Parkinson's disease mod

Iminium Carbonic Acid Derivative Salts. XI [1]. Synthesis of N,S-Containing Heterobicycles from N-Protected 2-Methylthio-1,3-thiazinium and 2-Methylthiothiazolium Salts. Part 3. Reaction of N-Protected 2-Methylthio-1,3-thiazinium and 2-Methylthiothiazolium Salts with 3-Amino-2-cyano-3-arylacrylonitriles

N-Boc-protected 2-methylthio-1,3-thiazinium 1 and 2-methylthiothiazolium iodides 2,3 obtained from the corresponding 3,4,5,6-tetrahydro-2H-1,3-thiazine-2-thiones and thiazolidine-2-thiones by the action of methyl iodide were reacted with 3-amino-2-cyano-3-arylacrylonitriles forming the cyclic isothioureas 5-7. The protection group was removed with trifluoroacetic acid whereupon the desired cyclisation to 3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazines 8a-c, 8a′-c′ and thiazolo[3,2-b]pyrimidines 9a,b, 9a′,b′, 10a,b took place.

SYNTHESIS AND FLASH VACUUM PYROLYSIS OF ISOXAZOLO- AND ISOTHIAZOLOPYRIMIDINES

The multi-step synthesis of isothiazolopyrimidines (1c, 1d) and isoxazolopyrimidine (1b) is described.Flash vacuum pyrolysis of 1b leads to phenyliminopropadienone, Ph-N=C=C=C=O, which was identified by Ar matrix infrared spectroscopy.

NEW ONE-POT SYNTHESIS OF ENAMINEDINITRILES

A convenient procedure is reported for the one-pot preparation of enaminedinitriles.This involves the sodium methoxide-catalysed addition of methanol to a suitably substituted nitrile followed by reaction of the resulting imidate with malononitrile.The mechanism, scope and limitations of the synthesis have been investigated.Spectroscopic evidence is presented that the products exist in the enaminedinitrile rather than in the tautomeric imino form.Various reactions of the compounds including halogen exchange, anion formation and amine displacement have been studied and used to extend the range of enaminedinitriles prepared.