33369-30-1

Usage

InChI:InChI=1/C17H18ClNO3/c1-4-22-15(20)10-14-9-11(2)16(19(14)3)17(21)12-5-7-13(18)8-6-12/h5-9H,4,10H2,1-3H3

Upstream product

• 33369-29-8 ethyl 3-carboxy-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetate 
• 17492-06-7 di-(p-chlorophenyl) cadmium 
• 52208-60-3 ethyl 1,4-dimethyl-5-chlorocarbonylpyrrole-2-acetate 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 10108-64-2 cadmium(II) chloride 
• 140-88-5 ethyl acrylate 
• 122-01-0 4-chloro-benzoyl chloride 
• 33369-47-0 ethyl 1,4-dimethyl-1H-pyrrole-2-acetate 
• 13014-48-7 4-chlorobenzoyl cyanide 

Downstream Products

• 33369-43-6 2-[5-(4-chloro-benzoyl)-1,4-dimethyl-pyrrol-2-yl]-propionic acid ethyl ester 
• 33369-31-2 zomepirac 

Relevant academic research and scientific papers

Synthesis of Pyrroles through Rhodium(III)-Catalyzed Reactions of Allylamines and Alkenes

Pyrrole derivatives are generated in reactions of allylamines with alkenes that are promoted by a Rh(III) catalyst in the presence of AgOAc. This process, which involves chelation assisted C-H bond activation and N-annulation, is applied to a three step synthesis of Zomepirac.

1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia

1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives for inhibiting neoplastic conditions.

Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives

Known types of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives are prepared by the thermal reaction of an aroylcyanide with a 1-alkylpyrrole-2-acetic acid derivative.

Preparation of 5-(arylcyanohydroxymethyl)-1-loweralkylpyrrole-2-acetic acid derivatives

5-(Arylcyanohydroxymethyl)-1-loweralkylpyrrole-2-acetic acid derivatives are prepared by the protic acid catalyzed reaction of aroylcyanides with 1-loweralkylpyrrole-2-acetic acid derivatives, which is then converted by treatment with alkali metal hydroxides or heat to form 5-aroyl-1-loweralkylpyrrole-2-acetic acid or derivatives thereof.

5-Chlorocarbonyl

A process of preparing certain 5-aroyl-pyrrole-2-alkanoic acid derivatives using phosgene and certain 5-unsubstituted pyrroles as starting materials, and certain novel 5-chlorocarbonyl-pyrrole precursors.

Aroyl-substituted pyrroles

The compounds are of the class of 5-aroyl-pyrrole alkanoic acids and corresponding acid derivatives thereof useful as anti-inflammatory agents and as synthetic intermediates.