333717-25-2

Upstream product

• 7757-38-2 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose 
• 100-39-0 benzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 
• 333717-22-9 4-methoxybenzyl 2,3-O-isopropylidene-α-D-lyxo-pentodialdo-1,4-furanoside 
• 333717-21-8 p-methoxybenzyl 6,7,8-trideoxy-5-O-benzyl-2,3-O-(1-methylethylidene)-α-D-manno-oct-7-enofuranoside 
• 333717-23-0 (R)-1-[(3aS,4R,6S,6aS)-6-(4-Methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-but-3-en-1-ol 

Downstream Products

• 154815-12-0 (3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-9-(phenylmethoxy)-1,3-dioxolo[4,5-a]indolizine 
• 85624-09-5 (3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-[1,3]dioxolo[4,5-a]indolizin-9-ol 
• 72741-87-8 swainsonine 

Relevant academic research and scientific papers

Allylated monosaccharides as precursors in triple reductive amination strategies: Synthesis of castanospermine and swainsonine

The feasibility of the triple-reductive amination reaction for the synthesis of complex indolizidine frameworks is illustrated by application to the potent glycosidase inhibitors castanospermine and swainsonine. The target compounds were obtained from known carbohydrate precursors in yields of 23 and 14%, over nine and 13 steps, respectively. The iodoetherification reaction of allylated monosaccharides was shown to be a practical reaction for the synthesis of the tricarbonyl precursors for the key triple reductive amination reactions.