33398-79-7Relevant academic research and scientific papers
NOVEL 5-HT2 ANTAGONISTS
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Paragraph 0110, (2017/01/05)
The present invention relates to 1-amidino-3-aryl-2-pyrazoline derivatives of the general formula I The invention specifically relates to such derivatives which exhibit antagonizing activity towards serotonin 5-HT2B receptors. The present invention also relates to use of said compounds as a medicament and for the treatment of fibrosis, cardiovascular diseases, pain, IBD, and other inflammatory diseases, as well as pharmaceutical compositions comprising one or more of said compounds and methods of treatment.
Synthesis and biological activity of guanylhydrazones of 2- and 4-pyridine and 4-quinoline carboxaldehydes
Foye,Almassian,Eisenberg,Maher
, p. 527 - 530 (2007/10/02)
A series of guanylhydrazones derived from 2- and 4-pyridine and 4-quinoline carboxaldehydes was synthesized from S-methylisothiosemicarbazide hydroiodide using known procedures. The compounds are analogous to anticancer and antiviral thiosemicarbazones, b
Cationic Antiprotozoal Drugs. Trypanocidal Activity of 2-(4'-Formylphenyl)imidazopyridinium Guanylhydrazones and Related Derivatives of Quaternary Heteroaromatic Compounds
Sundberg, Richard J.,Dahlhausen, Daniel J.,Manikumar, G.,Mavunkel, B.,Biswas, A.,et al.
, p. 298 - 307 (2007/10/02)
A series of quaternary 2-phenylimidazopyridinium salts has been prepared and evaluated for antiparasitic activity.Primary attention was focused on derivatives with amido, substituted hydrazone, and heterocyclic functionality at the para position of
